Carla J . H . van der Kallen

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The Maastricht Study is an extensive phenotyping study that focuses on the etiology of type 2 diabetes (T2DM), its classic complications, and its emerging comorbidities. The study uses state-of-the-art imaging techniques and extensive biobanking to determine health status in a population-based cohort of 10,000 individuals that is enriched with T2DM(More)
The study investigated cross-sectional associations of total amount and patterns of sedentary behaviour with glucose metabolism status and the metabolic syndrome. We included 2,497 participants (mean age 60.0 ± 8.1 years, 52% men) from The Maastricht Study who were asked to wear an activPAL accelerometer 24 h/day for 8 consecutive days. We calculated the(More)
Visfatin with the official gene name pre-B cell colony-enhancing factor 1 (PBEF) and the protein name nicotinamide phosphoribosyltransferase (NAMPT) is a recently discovered adipocyte-secreted protein that was shown by some to be associated with visceral fat and insulin resistance. To explore the link between PBEF/NAMPT/visfatin and lipid metabolism, we(More)
O besity, in particular central obesity, is characterized by a state of chronic low-grade inflammation (LGI) that has been linked to the increased risk of insulin resistance and type 2 diabetes mellitus (T2DM). Increasing evidence indicates that the adipose tissue is an active endocrine organ that produces several biological active mediators of LGI, which(More)
Evidence is accumulating that high serum concentrations of triacylglycerols (TAG) are, like LDL cholesterol, causally related to cardiovascular disease. A recent meta-analysis has indicated that plant stanol ester (PSE) intake not only lowered LDL cholesterol, but also serum TAG concentrations, especially in subjects with high baseline TAG concentrations.(More)
Several markers of iron metabolism have been associated with insulin resistance (IR) and type 2 diabetes mellitus in cross-sectional studies. However, prospective data on these associations are scarce, and it is currently unclear in which tissues iron metabolism may contribute to IR. Therefore, we investigated whether markers of iron metabolism were(More)
Daria V. Zhernakova1*, Patrick Deelen1,2*, Martijn Vermaat3*, Maarten van Iterson4*, Michiel van Galen3, Wibowo Arindrarto5, Peter van ’t Hof5, Hailiang Mei5, Freerk van Dijk1,2, Harm-Jan Westra6,7,8, Marc Jan Bonder1, Jeroen van Rooij9, Marijn Verkerk9, P. Mila Jhamai9, Matthijs Moed4, Szymon M. Kielbasa4 , Jan Bot10, Irene Nooren10, René Pool11, Jenny van(More)
The hyperglycaemic clamp technique and the frequently sampled IVGTT are unsuitable techniques to assess beta cell function (BCF) in large cohorts. Therefore, the aim of this study was to evaluate the discriminatory ability of simple OGTT-based BCF indices for prediction of prediabetes (meaning impaired fasting glucose and/or impaired glucose tolerance) and(More)