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The liver plays a pivotal role in metabolism and xenobiotic detoxification, processes that must be particularly efficient when animals are active and feed. A major question is how the liver adapts to… Continue Reading
Caloric restriction (CR) extends lifespan in mammals, yet the mechanisms underlying its beneficial effects remain unknown. The manner in which CR has been implemented in longevity experiments is… Continue Reading
BACKGROUND Bone marrow examination has been the confirmatory test for congenital dyserythropoietic anemia type II (CDAII). Occasional spherocytes on peripheral blood smear can confound the diagnosis.… Continue Reading
Congenital dyserythropoietic anaemia type II (CDAII, MIM 224100) is an autosomal recessive disorder of the bone marrow resulting in ineffective erythropoiesis. A characteristic diagnostic… Continue Reading