Sandra Macedo-Ribeiro2
Dominique Rousseau1
Ana Luísa Carvalho1
2Sandra Macedo-Ribeiro
1Dominique Rousseau
1Ana Luísa Carvalho
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Machado-Joseph disease (MJD/SCA3) is an autosomal dominant neurodegenerative disease caused by the expansion of a CAG tract in the coding portion of the ATXN3 gene. The presence of ubiquitin-positive aggregates of the defective protein in affected neurons is characteristic of this and most of the polyglutamine disorders. Recently, the accumulation of the(More)
Inhibitors of coagulation factors from blood-feeding animals display a wide variety of structural motifs and inhibition mechanisms. We have isolated a novel inhibitor from the cattle tick Boophilus microplus, one of the most widespread parasites of farm animals. The inhibitor, which we have termed boophilin, has been cloned and overexpressed in Escherichia(More)
BACKGROUND Patients with a left ventricular ejection fraction (LVEF) of less than 40 % are at high risk of developing postoperative low cardiac output syndrome (LCOS). Despite actual treatments (inotropic agents and/or mechanical assist devices), the mortality rate of such patients remains very high (13 to 24 %). The LICORN trial aims at assessing the(More)
In this paper we report on the design of a support system for autism therapists. The system was co-designed with a team of therapists working with autistic children and supports session management and data collection and analysis. It is integrated with a storytelling interactive environment in the context of improving the social skills of children with(More)
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