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- J Y Lambert, Carla A. Ibrahim-Verbaas, +179 authors Philippe Amouyel
- Nature Genetics
- 2013
Eleven susceptibility loci for late-onset Alzheimer's disease (LOAD) were identified by previous studies; however, a large portion of the genetic risk for this disease remains unexplained. We… (More)
- Cornelius A. Rietveld, Sarah E. Medland, +200 authors Philipp D Koellinger
- Science
- 2013
A genome-wide association study (GWAS) of educational attainment was conducted in a discovery sample of 101,069 individuals and a replication sample of 25,490. Three independent single-nucleotide… (More)
- Gail Davies, Nicola J Armstrong, +125 authors Ian J. Deary
- Molecular Psychiatry
- 2015
General cognitive function is substantially heritable across the human life course from adolescence to old age. We investigated the genetic contribution to variation in this important, health- and… (More)
- Rainer Malik, Steve N Bevan, +23 authors Martin Dichgans
- Stroke
- 2014
BACKGROUND AND PURPOSE
Genome-wide association studies have revealed multiple common variants associated with known risk factors for ischemic stroke (IS). However, their aggregate effect on risk is… (More)
- Benjamin F. J. Verhaaren, Stéphanie Debette, +99 authors Myriam Fornage
- Circulation. Cardiovascular genetics
- 2015
BACKGROUND
The burden of cerebral white matter hyperintensities (WMH) is associated with an increased risk of stroke, dementia, and death. WMH are highly heritable, but their genetic underpinnings… (More)
- Valentina Escott-Price, Céline Bellenguez, +185 authors Julie Williams
- PloS one
- 2014
BACKGROUND
Alzheimer's disease is a common debilitating dementia with known heritability, for which 20 late onset susceptibility loci have been identified, but more remain to be discovered. This… (More)
- Carla A. Ibrahim-Verbaas, Jan Bressler, +123 authors Thomas H. Mosley
- Molecular Psychiatry
- 2016
To identify common variants contributing to normal variation in two specific domains of cognitive functioning, we conducted a genome-wide association study (GWAS) of executive functioning and… (More)
- Carla A. Ibrahim-Verbaas, Myriam Fornage, +42 authors Lenore J. Launer
- Stroke
- 2014
BACKGROUND AND PURPOSE
Beyond the Framingham Stroke Risk Score, prediction of future stroke may improve with a genetic risk score (GRS) based on single-nucleotide polymorphisms associated with stroke… (More)
- Casper Jansen, Piero Parchi, +13 authors Annemieke J. M. Rozemuller
- PloS one
- 2012
Prion diseases are rare and fatal neurodegenerative disorders that can be sporadic, inherited or acquired by infection. Based on a national surveillance program in the Netherlands we describe here… (More)
- Christopher W Medway, Onofre Combarros, +24 authors Donald J. Lehmann
- European Journal of Human Genetics
- 2014
Epistasis between interleukin-10 (IL10) and aromatase gene polymorphisms has previously been reported to modify the risk of Alzheimer’s disease (AD). However, although the main effects of aromatase… (More)