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Performance suffers under NFS Version 2 because the protocol requires servers to write data and file system metadata to stable storage (usually disk) synchronously, before replying successfully to a client WRITE request [Ousterhout90]. The performance problem with synchronous writes was recognized early. NFS Version 2 has an artifact of a proposed interface(More)
We present fast methods for filtering voltage measurements and performing optimal inference of the location and strength of synaptic connections in large dendritic trees. Given noisy, subsampled voltage observations we develop fast l 1-penalized regression methods for Kalman state-space models of the neuron voltage dynamics. The value of the l 1-penalty(More)
This chapter discusses the design and development of a series of prototypes of a multimedia learning object for the mobile phone. It begins with the rationale for this development, and the underlying design and development principles of our learning objects. It then presents the iterative development process that ensued in creating four prototypes for the(More)
University of London has as part of its mission a commitment to innovating approaches to teaching, learning and assessment. It is with this in mind that I am particularly pleased to be able to introduce here the inaugural issue of the WLE Centre's Occasional Papers in Work-based Learning. The issue features a selection of research papers presented at a(More)
Bayesian Belief Network (BBN) modelling may be applied in rural extension in situations where program outputs are influenced by variables which are sequentially influenced by other variables. For a recently completed agroforestry extension program in Leyte the Philippines, BBN modelling of site factors, establishment practices and risk, predicted widely(More)
Inducible systems for gene expression emerge as a new class of artificial vectors offering temporal and spatial exogenous control of gene expression. However, most inducible systems are less efficient in vivo and lack the target-organ specificity. In the present study, we have developed and optimized an oligonucleotide-based inducible system for the in vivo(More)