Learn More
Prompt clinical diagnosis and timely treatment are the hallmarks of the proper care of diabetic patients with foot infections. The importance of careful clinical foot examination cannot be overemphasized. When infection is suspected, effort should be made to search for deeper infections, especially osteomyelitis. Numerous imaging techniques are available,(More)
All employees, including physicians, of a 450 bed hospital were monitored for puncture wounds from contaminated needles over a four-year period. Five hundred seventy-nine incidents were reported. Nurses were involved in 66% of instances, housekeeping 16%, laboratory workers 10%, physicians 4% and x-ray technicians 4%. Many puncture wounds were avoidable,(More)
We prospectively studied 30 adult patients with cellulitis, including many who were hospitalized with significant underlying medical problems. Needle aspiration of both central and leading edge areas of their lesions was performed in an attempt to establish a bacteriologic diagnosis. Potential pathogens were isolated by this technique in only 10% of the(More)
Because noninstitutionalized senior citizens comprise over 95% of the population 65 years of age and older, their health needs are a major concern. Data regarding infections in this population including the epidemiology, morbidity, and mortality are lacking. The authors recruited a study population of 417 free-living persons, all 65 years of age or older,(More)
Foot infections in diabetic patients are predominantly caused by gram-positive cocci, many of which are now antibiotic resistant. Because linezolid is active against these pathogens, we compared the efficacy and safety of intravenous and oral formulations with that of intravenous ampicillin-sulbactam and intravenous and oral amoxicillin-clavulanate given(More)
Because of the marked variability in presentation and management of osteomyelitis in patients, research with animal models that mimic the human disease offers a more controlled approach. Presently available animal models have been used to study pathogenesis, diagnosis, and treatment of osteomyelitis. Each model has advantages and disadvantages. Although it(More)
A previously-described experimental model of bacterial osteomyelitis was used to investigate systematically the sequential radiographic and histopathological changes in the tibias of rabbits infected with either Staphylococcus aureus or Pseudomonas aeruginosa. The radiographic changes induced by both organisms were progressive, increasing in severity from(More)
Azlocillin and tobramycin were used alone and in combination in the treatment of chronic osteomyelitis due to Pseudomonas aeruginosa in rabbits. This combination showed in vitro synergy measured by both the checkerboard technique and time-kill curves. A marked inoculum effect was demonstrated in vitro with azlocillin and the infecting strain of P.(More)