Carl Meacham

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STUDY OBJECTIVE To determine whether beta-adrenergic blocking agents affect exercise tolerance, exercise conditioning response, and blood pressure response to conditioning in hypertensive patients. DESIGN Randomized, double-blinded, placebo-controlled trial with a 10-week exercise period. SETTING Outpatient, monitored exercise program at a(More)
Forward genetics (phenotype-driven approaches) remain the primary source for allelic variants in the mouse. Unfortunately, the gap between observable phenotype and causative genotype limits the widespread use of spontaneous and induced mouse mutants. As alternatives to traditional positional cloning and mutation detection approaches, sequence capture and(More)
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