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Effects of infection and inflammation on lipid and lipoprotein metabolism: mechanisms and consequences to the host.

• Weerapan Khovidhunkit, M Kim, +4 authors Carl Grunfeld
• Journal of lipid research
• 2004

Infection and inflammation induce the acute-phase response (APR), leading to multiple alterations in lipid and lipoprotein metabolism. Plasma triglyceride levels increase from increased VLDL… (More)

Lipids, lipoproteins, triglyceride clearance, and cytokines in human immunodeficiency virus infection and the acquired immunodeficiency syndrome.

• Carl Grunfeld, Maoyin Pang, W T Doerrler, Judy K. Shigenaga, Pia V Jensen, Kenneth R. Feingold
• The Journal of clinical endocrinology and…
• 1992

Infection causes disturbances in lipid metabolism that may be mediated by cytokines. Therefore we studied plasma lipids, lipoproteins, triglyceride (TG) metabolism, and serum cytokines in three… (More)

Association of tenofovir exposure with kidney disease risk in HIV infection.

• Rebecca Scherzer, Michelle M. Estrella, +4 authors Michael G. Shlipak
• AIDS
• 2012

OBJECTIVE Despite widespread HAART use, HIV disease remains associated with increased risk of kidney disease. Whether tenofovir use is associated with higher risk of kidney disease is controversial.… (More)

Endotoxin and cytokines induce expression of leptin, the ob gene product, in hamsters.

• Carl Grunfeld, Connie Zhao, +4 authors Kennenth R Feingold
• The Journal of clinical investigation
• 1996

The expression of leptin, the ob gene product, is increased in adipose tissue in response to feeding and energy repletion, while leptin decreases food intake. Because adipose tissue gene expression… (More)

Management of metabolic complications associated with antiretroviral therapy for HIV-1 infection: recommendations of an International AIDS Society-USA panel.

• Morris Schambelan, Constance Ann Benson, +9 authors Michael S Saag
• Journal of acquired immune deficiency syndromes
• 2002

OBJECTIVE Alterations in glucose and lipid metabolism, lactic acidemia, bone disorders, and abnormal body fat distribution have been recognized recently as frequent complications associated with… (More)

Leptin regulation of the immune response and the immunodeficiency of malnutrition.

• Raffaella Faggioni, Kenneth R. Feingold, Carl Grunfeld
• FASEB journal : official publication of the…
• 2001

Leptin is a 16 kDa protein mainly produced by adipose tissue in proportion to adipose tissue mass. Originally thought to be a satiety factor, leptin is a pleiotropic molecule. In addition to playing… (More)

Endotoxin rapidly induces changes in lipid metabolism that produce hypertriglyceridemia: low doses stimulate hepatic triglyceride production while high doses inhibit clearance.

• Kennenth R Feingold, Ilona Staprans, +5 authors Carl Grunfeld
• Journal of lipid research
• 1992

Hyperlipidemia frequently accompanies infectious diseases and may be due to increases in lipoprotein production or decreases in lipoprotein clearance. The administration of endotoxin (LPS) has been… (More)

Preclinical atherosclerosis due to HIV infection: carotid intima-medial thickness measurements from the FRAM study.

• Carl Grunfeld, Joseph A Chris Delaney, +10 authors Richard A. Kronmal
• AIDS
• 2009

BACKGROUND Cardiovascular disease (CVD) is an increasing cause of morbidity and mortality in HIV-infected patients. However, it is controversial whether HIV infection contributes to accelerated… (More)

Leptin deficiency enhances sensitivity to endotoxin-induced lethality.

• Raffaella Faggioni, Giamila Fantuzzi, +4 authors Carl Grunfeld
• American journal of physiology. Regulatory…
• 1999

Leptin is induced by lipopolysaccharide (LPS) and cytokines. We investigated the role of leptin in LPS-induced toxicity using leptin-deficient ( ob/ ob) and leptin receptor-deficient ( db/ db) mice.… (More)

The acute phase response is associated with retinoid X receptor repression in rodent liver.

• Anne P. Beigneux, Arthur H. Moser, Judy K. Shigenaga, Carl Grunfeld, Kenneth R. Feingold
• The Journal of biological chemistry
• 2000

The acute phase response (APR) is associated with decreased hepatic expression of many proteins involved in lipid metabolism. The nuclear hormone receptors peroxisome proliferator-activated receptor… (More)

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