Carl Edward Schoonover

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The inner pore of voltage-gated Ca2+ channels (VGCCs) is functionally important, but little is known about the architecture of this region. In K+ channels, this part of the pore is formed by the S6/M2 transmembrane segments from four symmetrically arranged subunits. The Ca2+ channel pore, however, is formed by four asymmetric domains of the same (alpha1)(More)
Thalamus is a potent driver of cortical activity even though cortical synapses onto excitatory layer 4 neurons outnumber thalamic synapses 10 to 1. Previous in vitro studies have proposed that thalamocortical (TC) synapses are stronger than corticocortical (CC) synapses. Here, we investigated possible anatomical and physiological differences between these(More)
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In the brain, less is more. Many of the most successful methods in neuroscience research draw their power from stripping away all but the structures or phenomena relevant to a particular experimental question--focusing on the problem at hand, and cutting out the distractions. The birth of the modern field one century ago is due to the discovery of a tissue(More)
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