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Dholakia for editorial assistance. We are grateful to Saul Hoffman for bringing to our attention a set of systematic errors in the deflating of the monetary variables used in our analyses to real terms in a previous draft. All of these errors have been corrected. We especially wish to thank Robert Willis for numerous helpful discussions during the course of… (More)
In pursuit of the dream that patients' exercise of autonomy could extend beyond their span of competence, living wills have passed from controversy to conventional wisdom, to widely promoted policy. But the policy has not produced results, and should be abandoned.
CONTEXT Routine cancer screening with prostate-specific antigen (PSA) is controversial, and practice guidelines recommend that men be counseled about its risks and benefits. OBJECTIVE To evaluate the process of decision making as men react to and use information after PSA counseling. DESIGN Written surveys and semistructured qualitative interviews… (More)
The most popular current models of medical decision making, identified by names such as shared decision making, informed decision making, and evidence-based patient choice, portray an empowered patient actively involved in his or her medical choices and generally assume that patient and physician reach agreement. These models are limited to a specific type… (More)
We undertook a qualitative e-mail survey of federally-funded principal investigators of their views of the US human subjects protection system, intended to identify the range of investigator attitudes. This was an exploratory study with a 14% response rate. Twenty-eight principal investigators responded; their comments were analyzed to show underlying… (More)
Silymarin, the active extract from milk thistle, has been extensively used in patients with liver disease of different etiology. Although silymarin is a complex of 7 flavonolignans and polyphenols, silibinin is usually regarded as the most active component. In vitro and in vivo studies indicate that silymarin and silibinin protect the liver from oxidative… (More)
BACKGROUND Medication discrepancies are common when patients cross organisational boundaries. However, little is known about the frequency of discrepancies within mental health and the efficacy of interventions to reduce discrepancies. OBJECTIVE To evaluate the impact of a pharmacy-led reconciliation service on medication discrepancies on admissions to a… (More)