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Haemophilus ducreyi Associates with Phagocytes, Collagen, and Fibrin and Remains Extracellular throughout Infection of Human Volunteers
ABSTRACT In a previous study, Haemophilus ducreyi was found in the pustule and dermis of samples obtained at the clinical end point in the human model of infection. To understand the kinetics ofExpand
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Haemophilus ducreyi SapA Contributes to Cathelicidin Resistance and Virulence in Humans
ABSTRACT Haemophilus ducreyi is an extracellular pathogen of human epithelial surfaces that resists human antimicrobial peptides (APs). The organism's genome contains homologs of genes sensitive toExpand
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A fibrinogen-binding lipoprotein contributes to the virulence of Haemophilus ducreyi in humans.
A gene expression study of Haemophilus ducreyi identified the hypothetical lipoprotein HD0192, renamed here "fibrinogen binder A" (FgbA), as being preferentially expressed in vivo. To test the roleExpand
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Localization of Haemophilus ducreyi in naturally acquired chancroidal ulcers.
Haemophilus ducreyi causes the sexually transmitted genital ulcer disease chancroid. In human inoculation experiments, bacteria colocalize with neutrophils and macrophages but remain extracellular.Expand
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Differences in Host Susceptibility to Disease Progression in the Human Challenge Model of Haemophilus ducreyi Infection
ABSTRACT With human volunteers inoculated at two sites with Haemophilus ducreyi, outcomes for a subject were not independent. In a reinfection trial, 2 of 11 previous pustule formers and 6 of 10Expand
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Haemophilus ducreyi Is Resistant to Human Antimicrobial Peptides
ABSTRACT We examined the susceptibility of Haemophilus ducreyi to antimicrobial peptides likely to be encountered in vivo during human infection. H. ducreyi was significantly more resistant thanExpand
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