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Throughout infection, pathogenic bacteria induce dramatic changes in host transcriptional repertoires. An understanding of how bacterial factors influence host reprogramming will provide insight into disease pathogenesis. In the human respiratory pathogen Bordetella pertussis, the causative agent of whooping cough, pertussis toxin (PT) is a key virulence… (More)
The importance and contribution of replication research in nursing to the development of nursing science is discussed as well as deterrents which have apparently contributed to a dearth of replication studies in nursing. Various types and examples of replication studies are analyzed and criteria for replication in nursing are proposed.