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The nerve cords of organisms as diverse as nematodes, flies and humans embrace a common architecture with axial arrays of motoneurones distributed along midline bundles of neuronal processes (Hedgecock and Hall, 1990; Eisen, 1998; Jurata et al., 2000). In each case, locomotion depends on the coordinated activities of distinct classes of motoneurones, the(More)
Locomotory activity is defined by the specification of motoneurone subtypes. In the nematode, C. elegans, DA and DB motoneurones innervate dorsal muscles and function to induce movement in the backwards or forwards direction, respectively. These two neurone classes express separate sets of genes and extend axons with oppositely directed trajectories;(More)
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