Cara E. Ellis

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The development of the Edmonton Protocol encouraged a great deal of optimism that a cell-based cure for type I diabetes could be achieved. However, donor organ shortages prevent islet transplantation from being a widespread solution as the supply cannot possibly equal the demand. Porcine islet xenotransplantation has the potential to address these(More)
The virulence of 100, 54 and nine avian isolates of Pasteurella multocida for mice, chickens and turkey poults respectively was assessed and rated on a scale from 0 to 5. Cellular and colonial morphology of the bacteria was examined after mouse passage. There was evidence of a considerable range in the virulence of the isolates for the test species, but no(More)
Thirty-four rat carcases from 11 poultry farms were examined for the presence of Pasteurella multocida; 14 out of 34 (41 per cent) proved positive after mouse inoculation, compared with five out of 34 (14 per cent) using media alone. No salmonellae were recovered from 27 rat carcases using enrichment media. Poultry pasteurellosis was present on two farms(More)
Islet transplantation is an emerging strategy for treating patients with type 1 diabetes mellitus. Although the proof of concept for cellular replacement therapy in diabetes has been firmly established, vascularity of the transplant site and the long-term survival and function of transplanted islets remains suboptimal. In the present study, human(More)
Islet transplantation is a promising treatment for Type 1 diabetes; however limitations of the intra-portal site and poor revascularization of islets must be overcome. We hypothesize that engineering a highly vascularized collagen-based construct will allow islet graft survival and function in alternative sites. In this study, we developed such a(More)
Introduction: One of the alternatives to the daily insulin injection for the treatment of type I diabetes is a transplant of insulin producing tissue. However, islet graft survival requires chronic immunosuppression and in trials done so far, only 15% of recipients remain insulin independent at 5 years post-transplant (1). A major problem is poor(More)
One challenge that must be overcome to allow transplantation of neonatal porcine islets (NPIs) to become a clinical reality is defining a reproducible and scalable protocol for the efficient preparation of therapeutic quantities of clinical grade NPIs. In our standard protocol, we routinely isolate NPIs from a maximum of four pancreases, requiring tissue(More)
AIM To minimize the expansion of pancreatic mesenchymal cells in vitro and confirm that β-cell progenitors reside within the pancreatic epithelium. METHODS Due to mesenchymal stem cell (MSC) expansion and overgrowth, progenitor cells within the pancreatic epithelium cannot be characterized in vitro, though β-cell dedifferentiation and expansion of MSC(More)