Cara D. Varley

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No consensus exists on whether acyclovir prophylaxis should be given for varicella-zoster virus (VZV) prophylaxis after hematopoietic cell transplantation because of the concern of "rebound" VZV disease after discontinuation of prophylaxis. To determine whether rebound VZV disease is an important clinical problem and whether prolonging prophylaxis beyond 1(More)
OBJECTIVE In North America, tuberculosis and nontuberculous mycobacterial (NTM) disease rates associated with antitumour necrosis factor α (anti-TNFα) therapy are unknown. METHODS At Kaiser Permanente Northern California, the authors searched automated pharmacy records to identify inflammatory disease patients who received anti-TNF therapy during(More)
BACKGROUND Oseltamivir is safe and effective in immunocompetent persons, and prophylactic use is recommended during influenza outbreaks. However, no data exist regarding the use of oseltamivir as prophylaxis among patients undergoing hematopoietic stem cell transplantation (HSCT). METHODS In January 2002, an influenza A outbreak was identified when 4(More)
PURPOSE Anti-tumor necrosis factor-alpha (anti-TNF) therapies are associated with severe mycobacterial infections in rheumatoid arthritis patients. We developed and validated electronic record search algorithms for these serious infections. METHODS The study used electronic clinical, microbiologic, and pharmacy records from Kaiser Permanente Northern(More)
OBJECTIVE We investigated the relationship between Staphylococcus aureus colonization and the use of immunosuppressive therapies in patients with immune-mediated inflammatory diseases (IMIDs). METHODS We prospectively enrolled IMID patients from the rheumatology and dermatology departments of Oregon Health & Science University. At enrolment, we surveyed(More)
To determine whether tuberculosis (TB) and nontuberculous mycobacteria (NTM) infection patients could be distinguished from one another with limited information, we compared pulmonary TB and NTM patients during 2005-2006. Our finding that age, birthplace, and presence of chronic obstructive pulmonary disease could differentiate TB and NTM disease could(More)
We looked for non-tuberculous mycobacteria (NTM) in the sputum of patients diagnosed with pulmonary tuberculosis (TB) in Oregon in 2005-2006 (n = 141). Twenty (14%) patients had NTM isolated from sputum during TB treatment. Compared to those without NTM, TB patients with NTM were more likely to have cavitary disease (RR 2.7, 95%CI 1.2-6.0) and were more(More)
Colonic perforation is an unusual complication of colonoscopy. We present a case of pneumothorax, pneumomediastinum, pneumoperitoneum and extensive subcutaneous emphysema resulting from a diagnostic colonoscopy. To our knowledge, only two such cases have been described previously.
form at the Infectious Diseases Society of America conference, October 2010, Vancouver, British Columbia, Canada. We acknowledge the assistance of NTMir.org in helping to fund this study. The work of K.L.W. was funded by an Agency for Healthcare Research and Quality grant (1K08HS017552-01) and a grant from NTMir.org. Kevin L. Winthrop, Cara D. Varley, Jill(More)
Nasolacrimal tuberculosis is rare. The authors present a young Peruvian-born female with subacute onset of right eye epiphora, isolated right inferior turbinate enlargement, and ipsilateral cervical lymphadenopathy. Turbinate and neck mass incisional biopsies demonstrated histopathological findings consistent with tuberculosis. QuantiFERON-TB Gold-In-Tube(More)