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Natriuretic peptides and therapeutic applications
The NP system thus serves as an important compensatory mechanism against neurohumoral activation in heart failure and provides a strong rationale for the use of exogenous NPs in the management of acutely decompensated heart failure.
Inhibitory Profile of SEA0400 [2-[4-[(2,5-Difluorophenyl)methoxy]phenoxy]-5-ethoxyaniline] Assessed on the Cardiac Na+-Ca2+ Exchanger, NCX1.1
The data confirm that SEA0400 is the most potent inhibitor of the cardiac Na+-Ca2+ exchanger described to date and provide a reasonable explanation for its apparent transport mode selectivity.
Therapeutic potential of novel Na+-Ca2+ exchange inhibitors in attenuating ischemia-reperfusion injury.
The cardiac Na+-Ca2+ exchanger (NCX) plays an essential role in regulating Ca2+ under physiological and pathophysiological conditions and has shown great promise in attenuating ischemia-reperfusion injury.
A novel chimeric natriuretic peptide reduces cardiomyocyte hypertrophy through the NHE-1-calcineurin pathway.
This study demonstrates a direct anti-hypertrophic effect of the chimeric peptide CU-NP via NHE-1 inhibition, thereby preventing calcineurin activation and NFAT nuclear import.
Integrin α9β1 in airway smooth muscle suppresses exaggerated airway narrowing.
It is shown that integrin α9β1 on airway smooth muscle localizes the polyamine catabolizing enzyme spermidine/spermine N1-acetyltransferase (SSAT) in close proximity to the lipid kinase PIP5K1γ, which facilitates local catabolism of polyamines and thereby inhibits PIP1γ.
Pharmacodynamics Pharmacodynamics of a Novel Designer Natriuretic Peptide, CD‐NP, in a First‐in‐Human Clinical Trial in Healthy Subjects
First successful clinical testing of a chimeric NP demonstrating in normal human volunteers that CD‐NP possesses cyclic guanosine monophosphate—activating, natriuretic, and aldosterone‐suppressing properties without inducing excessive hypotension is reported, laying the foundation for additional studies on this first‐in‐class new cardiovascular therapeutic in human heart failure.
Designer Natriuretic Peptides
Designer natriuretic peptides (NPs) are novel hybrid peptides that are engineered from the native NPs through addition, deletion, or substitution of amino acid(s) with a goal toward optimization of
Myocardial Alterations in Senescent Mice and Effect of Exercise Training: A Strain Rate Imaging Study
Chronic exercise normalizes LV systolic function and decreases fibrosis in old mice and strain rate imaging in mice may be a useful tool to monitor the effect of new therapeutic strategies preventing the myocardial dysfunction associated with aging.