Canan Ozsancak

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Dysarthria in Parkinson's disease can be characterised by monotony of pitch and loudness, reduced stress, variable rate, imprecise consonants, and a breathy and harsh voice. Use of levodopa to replenish dopamine concentrations in the striatum seems to improve articulation, voice quality, and pitch variation, although some studies show no change in phonatory(More)
In Parkinson's disease (PD), festination corresponds to a tendency to speed up when performing repetitive movements. First described in gait (and then in handwriting and speech), festination is one of the most disabling axial symptoms. To establish the phenomenology of oral festination (OF) and the condition's potential links with other axial disorders, we(More)
13 Low-frequency vocal modulations here designate slow disturbances of the phonatory 14 frequency F0. They are present in all voiced speech sounds, but their properties 15 may be affected by neurological disease. An analysis method, based on continuous 16 wavelet transforms, is proposed to extract the phonatory frequency trace and low17 frequency vocal(More)
Vocal tremor is encountered in different neurological diseases and could be used for their characterisation. In this paper, vocal tremor features have been extracted for speakers with Parkinson’s disease and control speakers. It is shown that Parkinson’s disease has significant effects on vocal tremor features. For speakers with Parkinson’s disease, the(More)
The treatment of speech impairment, a factor of loneliness, speech therapy to treat dysarthria in Parkinson's disease is a fundamental aspect of patient management. The impact of medicinal treatment of dysarthria is controversial and surgery appears to worsen the problem. Various speech therapy approaches are relaxation, postural rehabilitation,(More)
BACKGROUND Amyloid protein precursor (APP), presenilin-1 (PSEN1), and presenilin-2 (PSEN2) mutations cause autosomal dominant forms of early-onset Alzheimer disease (AD-EOAD). Although these genes were identified in the 1990s, variant classification remains a challenge, highlighting the need to colligate mutations from large series. METHODS AND FINDINGS(More)
Terminal deletion of the long arm of the chromosome 10 is a rare but well known abnormality, with a large phenotypic variability. Very few data are available about subtelomeric deletion 10q26 patients without intellectual disability. Herein, we report the case of a young adult with a classical 10q26.2qter deletion. She exhibited mainly short stature at(More)
The effect of intensive voice therapy (Lee Silverman Voice Treatment, LSVT) on vocal tremor features of Parkinson speakers is presented. Vocal tremor is the low-frequency variation of the vocal frequency. Its features differ for Parkinson and normophonic speakers. Here, vocal tremor features have been estimated for a corpus of speakers with Parkinson’s(More)
The objective of this paper is to present a formant frequency estimation method, developed with a view to track small variations due to involuntary vocal tract movement. The formant frequency estimation is based on the instantaneous frequencies obtained by means of a complex wavelet transform and is synchronised with the glottal cycle. Results for synthetic(More)
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