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BACKGROUND The -1082G/A polymorphism in IL-10 gene has been extensively investigated for association to Alzheimer's disease (AD), however, results of different studies have been inconsistent. The objective of this study is to assess the relationship of IL-10 -1082G/A polymorphism and AD risk by using meta-analysis. METHODS All eligible case-control(More)
BACKGROUND Polymorphisms in the cytotoxic T-lymphocyte antigen 4 (CTLA-4) gene have been implicated in susceptibility to cancer, but the many published studies have reported inconclusive results. The objective of the current study was to conduct a meta-analysis investigating the association between polymorphisms in the CTLA-4 gene and the risk of cancer. (More)
The −159C/T polymorphism in the CD14 gene has been implicated in susceptibility to asthma, but a large number of studies have reported inconclusive results. The aim of this study is to investigate the association between the −159C/T polymorphism in the CD14 gene and the risk of asthma by meta-analysis. We searched Pubmed, Embase, CNKI database, Wanfang(More)
The −308 G/A polymorphism in TNF-α gene has been extensively investigated for association to asthma; however, results of different studies have been inconsistent. The aim of this study is to comprehensively evaluate the genetic risk of −308 G/A polymorphism in TNF-α gene for asthma. A meta-analysis was carried out to analyze the association between the −308(More)
The insertion/deletion (I/D) polymorphism in the Angiotensin-converting enzyme (ACE) gene has been implicated in susceptibility to cancer, but a large number of studies have reported inconclusive results. The aim of this study is to assess the association between the I/D polymorphism in the ACE gene and cancer risk by meta-analysis. A search was performed(More)
BACKGROUND The -2518A/G polymorphism in the monocyte chemoattractant protein-1 (MCP-1) gene has been implicated in the susceptibility to tuberculosis (TB), but the results are not conclusive. The aim of this study is to investigate the association between the -2518A/G polymorphism in the MCP-1 gene and the risk of tuberculosis by meta-analysis. METHODS We(More)
BACKGROUND Published data regarding the associations between genetic variants and asthma risk in Chinese population were inconclusive. The aim of this study was to investigate asthma susceptible genes in Chinese population. METHODS The authors conducted 18 meta-analyzes for 18 polymorphisms in 13 genes from eighty-two publications. RESULTS Seven(More)
The +874T/A polymorphism in the interferon-γ (IFN-γ) gene has been extensively examined for association to tuberculosis (TB); however, results of different studies have been inconsistent. The aim of this study was to comprehensively analyze the genetic risk of the +874T/A polymorphism in IFN-γ gene for TB by meta-analysis. A total of 4553 cases and 4631(More)
BACKGROUND AND AIMS RANTES is a chemokine that assists the recruitment of inflammatory cells including eosinophils. Previous studies revealed that polymorphisms of RANTES were implicated in susceptibility to asthma, but a large number of studies reported apparently conflicting results. We performed a meta-analysis to investigate the association of these(More)
BACKGROUND AND OBJECTIVE Polymorphisms in the transforming growth factor-beta1 (TGF-beta1) gene have been implicated in susceptibility to asthma, but a large number of studies have reported inconclusive results. A meta-analysis was performed to investigate the association between polymorphisms in the TGF-beta1 gene and asthma susceptibility. METHODS(More)