Campbell M. Clark

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Electroconvulsive therapy (ECT) is one of the most effective therapies for depression and has beneficial motor effects in parkinsonian patients. However, little is known about the mechanisms of therapeutic action of ECT for either condition. The aim of this work was to explore the impact of ECT on dopaminergic function in the striatum of non-human primates.(More)
Multi-echo T(2) relaxation decay data was acquired for 5 preadolescent males (age range 9-12 years). A signal to noise filter appropriate for multi-exponential T(2) analysis was then applied to remove voxels which did not accurately fit the modelled curve. The remaining voxels were designated "highly myelinated" if their myelin water fraction (MWF) was(More)
Prolactin (PRL) plasma levels rise several fold in response to electroconvulsive therapy (ECT). There is evidence that the magnitude of ECT-induced PRL release varies as a function of electrode placement with bilateral (BL) ECT, producing a larger PRL increase than does unilateral (UL) ECT. Although there is some evidence that the amount of PRL released by(More)
Buspirone-stimulated prolactin release has been employed as an indirect measure of central serotonin activity; however, it is not clear whether serotonergic or dopaminergic systems are responsible for this response. In an attempt to further elucidate the mechanism, we studied the prolactin response to buspirone in eight subjects in the presence of maximal(More)
BACKGROUND Electroconvulsive therapy (ECT), an effective treatment for depression, also improves motor symptomatology in Parkinson's disease (PD). We have previously demonstrated that ECT stimulates dopamine (DA) function in the striatum of healthy non-human primates, suggesting that DA may contribute to antidepressant effects. OBJECTIVE We investigated(More)
PSYCHOLOGY Funcionamento executivo e desempenho em leitura na escola: um estudo de crianças Brasileiras identificadas por seus professores como " Maus Leitores " crianças em situação de risco para fracasso escolar. INTRODUÇÃO A leitura é uma tarefa complexa que depende de uma série de habilidades. Atualmente, está claro que as habilidades de consciência(More)
In Japan, admission to a psychiatric facility for people with schizophrenia is usually for life. We developed a rehabilitation program aimed at discharging these patients into the Tokyo community. This paper describes the results for the 224 patients. Using an inpatient ward at the Tokyo Musashino Hospital, patients were enrolled in the program and(More)
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