Campbell M. Clark

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Electroconvulsive therapy (ECT) is one of the most effective therapies for depression and has beneficial motor effects in parkinsonian patients. However, little is known about the mechanisms of therapeutic action of ECT for either condition. The aim of this work was to explore the impact of ECT on dopaminergic function in the striatum of non-human primates.(More)
The purpose of this study was to determine the reproducibility and reliability of five MRI-derived measurements, namely, total water content (WC), myelin water content (MWC), mean T2 relaxation time (GMT2), T1 relaxation time (T1) and magnetization transfer ratio (MTR). Five controls were scanned 5 times over 1 year. The five MR measurements were made for 5(More)
Multi-echo T(2) relaxation decay data was acquired for 5 preadolescent males (age range 9-12 years). A signal to noise filter appropriate for multi-exponential T(2) analysis was then applied to remove voxels which did not accurately fit the modelled curve. The remaining voxels were designated "highly myelinated" if their myelin water fraction (MWF) was(More)
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