Learn More
The architecture of the pulvinar of rhesus monkeys was investigated by acetylcholinesterase (AChE) histochemistry, and by immunocytochemistry for calbindin-D28k and the SMI-32 antibody. The presence of four inferior subdivisions, comparable to those found in architectonic-connectional studies in squirrel monkeys (C.G. Cusick, J.L. Scripter, J.G.(More)
To investigate the organization of the dorsal pulvinar complex, patterns of neurochemical staining were correlated with cortico-pulvinar connections in macaques (Macaca mulatta). Three major neurochemical subdivisions of the dorsal pulvinar were identified by acetylcholinesterase (AChE) histochemistry, as well as immunostaining for calbindin-D(28K) and(More)
To investigate whether the inferior pulvinar complex has a common organization in different primates, the chemoarchitecture of the visual thalamus was re-examined in squirrel monkeys (Saimiri sciureus) and macaques (Macaca mulatta). The inferior pulvinar (PI) complex consisted of multiple subdivisions and encompassed the classic PI, and adjacent ventral(More)
To examine how fibers from functionally distinct cortical zones interrelate within their target areas of the superior temporal sulcus (STS) in the rhesus monkey, separate anterograde tracers were injected in two different regions of the same hemisphere known to project to the STS. Paired injections were placed in dorsal prearcuate cortex and the caudal(More)
To investigate how visuotopic connections relate to chemoarchitecture of the inferior pulvinar (PI) complex in macaques, neuroanatomical tracers were placed into known portions of the visual representation in V1. Separate foci of label associated with both the upper and lower visual quadrants occupied neurochemically defined medial, central, lateral, and(More)
BACKGROUND Interferon beta (IFNbeta) lessens the overall frequency of acute attacks in patients with the relapsing-remitting form of multiple sclerosis (RRMS). IFNbeta may act by decreasing the synthesis of inflammatory cytokines. OBJECTIVES To determine whether IFNbeta-1b treatment had an initial and sustained effect on the in vivo synthesis and(More)
The calcium binding proteins parvalbumin and calbindin-D28k were localized immunocytochemically within the lateral geniculate nucleus of adult monkeys at 1-7 months after monocular enucleation. Within the deafferented magno- and parvocellular layers, parvalbumin and calbindin-D28k immunoreactive fibers were depleted at all post-enucleation times. The(More)
We report the clinical and pathologic features of a patient with peripheral neuropathy that was the first clinical expression of cholesterol emboli syndrome (CES). Biopsy of skeletal muscle and peripheral nerve revealed cholesterol clefts in lumens of small arteries, necrotizing arteritis, and severe degeneration of peripheral and intramuscular nerves. At(More)
High doses of glucocorticoids (GCs) are widely employed to treat acute attacks in relapsing-remitting multiple sclerosis (MS) patients. Their beneficial effects are partially due to their capacity to regulate the cytokine network. In the present work, we have examined the effect of GCs on the production of the immunosuppressor cytokine IL-10. Blood samples(More)