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BACKGROUND Low levels of total 25-hydroxyvitamin D are common among black Americans. Vitamin D-binding protein has not been considered in the assessment of vitamin D deficiency. METHODS In the Healthy Aging in Neighborhoods of Diversity across the Life Span cohort of blacks and whites (2085 participants), we measured levels of total 25-hydroxyvitamin D,(More)
Studies examining the relationship between total circulating 25-hydroxyvitamin D [25(OH)D] levels and bone mineral density (BMD) have yielded mixed results. Vitamin D-binding protein (DBP), the major carrier protein for 25(OH)D, may alter the biologic activity of circulating vitamin D. We hypothesized that free and bioavailable 25(OH)D, calculated from(More)
Previous studies report an association between vitamin D deficiency and hypertension, including the pregnancy-specific disorder preeclampsia. Circulating vitamin D is almost entirely bound to vitamin D binding protein, which increases 2-fold during pregnancy and previous studies have not examined vitamin D binding protein or free vitamin D levels. We(More)
To the Editor: Current assays for vitamin D sufficiency measure total circulating 25-hydroxyvitamin D. However, Powe et al. (Nov. 21 issue)1 conclude that measurement of 25-hydroxyvitamin D that is not bound to the vitamin D–binding protein, which they refer to as bioavailable 25-hydroxyvitamin D, provides a better assessment of sufficiency. They report(More)
P reeclampsia is a clinical syndrome defined as the new onset of hypertension and proteinuria during the second half of pregnancy. 1 It afflicts 3% to 5% of pregnancies and is a leading cause of maternal mortality, especially in developing countries. 2,3 Because the only known remedy is delivery of the placenta, in developed countries preeclamp-sia is an(More)
BACKGROUND An imbalance in circulating angiogenic factors plays a central role in the pathogenesis of preeclampsia. METHODS AND RESULTS We prospectively studied 616 women who were evaluated for suspected preeclampsia. We measured plasma levels of antiangiogenic soluble fms-like tyrosine kinase 1 (sFlt1) and proangiogenic placental growth factor (PlGF) at(More)
Prior studies showed conflicting results regarding the association between 25-hydroxyvitamin D (25(OH)D) levels and mineral metabolism in end-stage renal disease. In order to determine whether the bioavailable vitamin D (that fraction not bound to vitamin D-binding protein) associates more strongly with measures of mineral metabolism than total levels, we(More)
OBJECTIVE To compare the clinical characteristics and outcomes of preeclamptic women presenting with a normal plasma angiogenic profile with those subjects who are characterized by an abnormal angiogenic profile. METHODS This was a secondary analysis of a prospective cohort study in women presenting to obstetrical triage at <37 weeks of gestation and(More)
OBJECTIVE To determine whether maternal levels of follistatin-like-3 (FSTL3), an inhibitor of activin and myostatin involved in glucose homeostasis, are altered in the first trimester of pregnancies complicated by subsequent gestational diabetes mellitus (GDM). RESEARCH DESIGN AND METHODS This was a nested case-control study of subjects enrolled in a(More)