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Discuss this article (0) Comments 3 2 1 RESEARCH ARTICLE Does excitatory fronto-extracerebral tDCS lead to improved working memory performance? [v2; ref status: indexed, http://f1000r.es/2ic] Previously titled: Does excitatory fronto-extracephalic tDCS lead to improved working memory performance? Abstract Evidence suggests that excitatory transcranial(More)
The habenula is a small, evolutionarily conserved brain structure that plays a central role in aversive processing and is hypothesised to be hyperactive in depression, contributing to the generation of symptoms such as anhedonia. However, habenula responses during aversive processing have yet to be reported in individuals with major depressive disorder(More)
Evidence suggests that excitatory transcranial direct current stimulation (tDCS) may improve performance on a wide variety of cognitive tasks. Due to the non-invasive and inexpensive nature of the method, harnessing its potential could be particularly useful for the treatment of neuropsychiatric illnesses involving cognitive dysfunction. However, questions(More)
Transcranial direct current stimulation (tDCS) is a noninvasive neuromodulatory technique with putative cognitive enhancing and therapeutic applications. Since the year 2000, almost 1000 papers have been published on tDCS, reflecting the possible significance of a cheap, safe, and easily applied neuromodulatory technology. Whether or not this potential is(More)
There is considerable need to develop tailored approaches to psychiatric treatment. Numerous researchers have proposed using functional magnetic resonance imaging (fMRI) biomarkers to predict therapeutic response, in particular by measuring task-evoked subgenual anterior cingulate (sgACC) and amygdala activation in mood and anxiety disorders. Translating(More)
It would be maladaptive to learn about catastrophes by trial and error alone. Investment in planning and effort are necessary. Devoting too many resources to averting disaster, however, can impair quality of life, as in anxiety and paranoia. Here, we developed a novel task to explore how people adjust effort expenditure (vigor) so as to avoid negative(More)
Evidence for endemically low statistical power has recently cast neuroscience findings into doubt. If low statistical power plagues neuroscience, this reduces confidence in reported effects. However, if statistical power is not uniformly low, such blanket mistrust might not be warranted. Here, we provide a different perspective on this issue, analysing data(More)
Transcranial direct current stimulation (tDCS) has recently garnered attention as a putative depression treatment. However, the cognitive mechanisms by which it exerts an antidepressant effect are unclear: tDCS may directly alter 'hot' emotional processing biases, or alleviate depression through changes in 'cold' (non-emotional) cognitive function. Here, 75(More)