Camila CM de Oliveira

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Trypanosome gene expression is regulated almost exclusively at the posttranscriptional level, through mRNA stability, storage and degradation. Here, we characterize the ribonucleoprotein complex (mRNPs) corresponding to the zinc finger protein TcZC3H39 from T. cruzi comparing cells growing in normal conditions and under nutritional stress. The nutritional(More)
Regulation of gene expression in trypanosomatids is mainly posttranscriptional. Tight regulation of mRNA stability and access to polysomes allows Trypanosoma cruzi to adapt to different environmental conditions during its life cycle. Posttranscriptional regulation requires association between mRNAs and specific proteins to form mRNP complexes. Proteins that(More)
RNA-binding proteins (RBPs) have important functions in the regulation of gene expression. RBPs play key roles in post-transcriptional processes in all eukaryotes, such as splicing regulation, mRNA transport and modulation of mRNA translation and decay. RBPs assemble into different mRNA-protein complexes, which form messenger ribonucleoprotein complexes(More)
Antônio Carlos C Freire1*, Camila CM de Oliveira2 and Milena Pereira Pondé3 1Escola Baiana de Medicina e Saúde Pública, Hospital Juliano Moreira, Salvador, Bahia, Brazil 2Escola Baiana de Medicina e Saúde Pública (EBMSP), EBMSP Research Group in Endocrinopathies during Pregnancy, Maternidade José Maria Magalhães Neto, Salvador, Bahia, Brazil 3Escola Baiana(More)
The regulation of gene expression in trypanosomatids occurs mainly at the post-transcriptional level. Despite the importance of this type of control in Trypanosoma cruzi, few RNA binding proteins have been characterized. The RRM domain (RNA Recognition Motif) is one of the most abundant domains found in RNA-binding proteins in higher eukaryotes. Proteins(More)
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