Calvin Zhang

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We examine the phase response properties of half-center oscillators (HCOs) that are modeled by a pair of Morris-Lecar-type neurons connected by strong fast inhibitory synapses. We find that the two basic mechanisms for half-center oscillations, “release” and “escape”, give rise to strikingly different phase response curves (PRCs). Release-type HCOs are most(More)
Lateral clustering has emerged as a general mechanism used by many cellular receptors to control their responses to critical changes in the external environment. Here we derive a general mathematical framework to characterize the effect of receptor clustering on the sensitivity and dynamic range of biochemical signaling. In particular, we apply the theory(More)
Introduction Because proteins that have diverged beyond significant sequence similarity still retain the three-dimensional (3D) fold of their ancestor (Chothia and Lesk, 1986; Rost, 1997), the recognition of structural similarity between proteins provides powerful clues to ancestry. In fact, a large number of distant homology relationships were identified(More)
The probabilistic nature of neurotransmitter release in synapses is believed to be one of the most significant sources of noise in the central nervous system. We show how p0, the probability of release per docked vesicle when an action potential arrives, affects the dynamics of the rate of vesicle release in response to changes in the rate of arrival of(More)
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