Calvin K. Young

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Theta oscillations in the hippocampus support cognitive processing. Theta-range rhythmicity has also been reported in frontal and posterior cortical areas--where it tends to show consistent phase-relations with hippocampal rhythmicity. Theta-range rhythmicity may, then, be important for cortico-cortical and/or cortico-hippocampal interactions. Here, we(More)
Oscillatory brain activities have been traditionally studied in the context of how oscillations at a single frequency recorded from a single area could reveal functional insights. Recent advances in methodology used in signal analysis have revealed that cross-frequency coupling, within or between functional related areas, is more informative in determining(More)
Identification of active networks involved in behavior is central to understanding brain function as an emergent property. Functional magnetic resonance imaging (fMRI) allows the identification of areas with increased or decreased activity, but the cellular correlates to changes in fMRI response is still controversial. Deep brain stimulation of the(More)
Deep brain stimulation (DBS) of the subthalamic nucleus has been used extensively in the treatment of Parkinson's disease. However, the efficacy of such treatments on bradykinesia/akinesia remains low. DBS of the posterior hypothalamic nucleus (PH) elicits spontaneous, non-stereotypical motor behaviours. We tested the hypothesis that PH stimulation could(More)
Previous studies have shown only modest effects of supramammillary nucleus (SuM) dysfunction on theta frequency and learning in the water maze (WM), with larger effects in other tasks. However, theta recorded from SuM, and used to trigger the production of theta-like oscillations in the hippocampus, produced reversal of the deficit in WM learning produced(More)
The function of hippocampal theta oscillations has been subjected to constant speculation. Dynamic coupling of theta field potentials and spiking activity between the hippocampus and extra-hippocampal structures emphasizes the importance of theta-frequency oscillations in global spike-timing precision in the brain. Recent advances in understanding theta(More)
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