Calvin J. Meaney

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OBJECTIVES Using a family study design, we describe the motor and nonmotor phenotype in probands with LRRK2 G2019S mutations and family members and compare these individuals to patients with idiopathic Parkinson disease (iPD) and unrelated controls. METHODS Probands with G2019S mutations and their first-degree relatives, subjects with iPD, and unrelated(More)
BACKGROUND After renal transplantation, many patients experience adverse effects from maintenance immunosuppressive drugs. When these adverse effects occur, patient adherence with immunosuppression may be reduced and impact allograft survival. If these adverse effects could be prospectively monitored in an objective manner and possibly prevented, adherence(More)
Extrarenal adverse effects (AEs) associated with calcineurin inhibitor (CNI) and mycophenolic acid (MPA) occur frequently but are unpredictable posttransplant complications. AEs may result from intracellular CNI accumulation and low activity of P-glycoprotein, encoded by the ABCB1 gene. Since ABCB1 single nucleotide polymorphisms (SNPs) and sex influence(More)
A community mental health center established a group lithium clinic to introduce a medical model of treatment for manic-depressive patients and to reduce staff time in caring for these patients. Clinical maintenance consisted of a monthly group meeting with a psychiatrist and a social worker; the social worker led general discussions on symptomatology, the(More)
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