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Clostridium sordellii genome analysis reveals plasmid localized toxin genes encoded within pathogenicity loci
Genome analysis of C. sordellii reveals that the LCCs, the major virulence factors, are localised on plasmids, similar to C. difficile, but LCC-negative strains may precipitate certain categories of infection. Expand
pCP13, a representative of a new family of conjugative toxin plasmids in Clostridium perfringens.
It is demonstrated that pCP13 is in fact conjugative, transfers at high frequency and that the newly defined Pcp conjugation locus encodes putative homologues of a type 4 secretion system (T4SS), one of which, PcpB4, was shown to be essential for transfer. Expand
Virulence Plasmids of the Pathogenic Clostridia.
- Sarah A. Revitt-Mills, Callum J Vidor, T. Watts, D. Lyras, J. Rood, V. Adams
- Medicine, Biology
- Microbiology spectrum
- 17 May 2019
The mobile nature of these toxin genes gives a ready explanation of how clostridial toxin genes have been so widely disseminated both within the clastridial genera as well as in the wider bacterial community. Expand
Antibiotic resistance, virulence factors and genetics of Clostridium sordellii.
This review will summarise studies involving the genetics of C. sordellii, including an antibiotic resistance profile, the genetic determinants of virulence and mutagenesis, and how it causes disease. Expand
Clostridium sordellii Pathogenicity Locus Plasmid pCS1-1 Encodes a Novel Clostridial Conjugation Locus
The ability of a plasmid carrying the tcsL gene to undergo conjugative transfer between distantly related strains of C. sordellii has been shown, showing broad implications for the dissemination of virulence genes among members of a diverse range of clostridial pathogens. Expand
Repurposing auranofin as a Clostridioides difficile therapeutic.
- M. L. Hutton, H. Pehlivanoğlu, Callum J Vidor, M. James, M. Thomson, D. Lyras
- The Journal of antimicrobial chemotherapy
- 23 October 2019
Auranofin significantly reduces sporulation and toxin production under in vitro conditions and in infected mice in vivo, and shows promise as a prospective therapeutic option for C. difficile infections. Expand
Paeniclostridium sordellii and Clostridioides difficile encode similar and clinically relevant tetracycline resistance loci in diverse genomic locations
The Tet P determinant is found in variable genomic locations within diverse human and animal isolates of P. sordellii and C. difficile, which suggests that it can undergo horizontal transfer, and may disseminate tetracycline resistance between clostridial species. Expand