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Hippo Pathway-independent Restriction of TAZ and YAP by Angiomotin*
The Hippo pathway restricts the activity of transcriptional co-activators TAZ and YAP by phosphorylating them for cytoplasmic sequestration or degradation. In this report, we describe an independentExpand
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TEADs Mediate Nuclear Retention of TAZ to Promote Oncogenic Transformation*
The transcriptional coactivators YAP and TAZ are downstream targets inhibited by the Hippo tumor suppressor pathway. The expression level of TAZ is recently shown to be elevated in invasive breastExpand
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The hippo pathway in biological control and cancer development
The Hippo pathway is an evolutionally conserved protein kinase cascade involved in regulating organ size in vivo and cell contact inhibition in vitro by governing cell proliferation and apoptosis.Expand
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Targeting Intracellular Oncoproteins with Antibody Therapy or Vaccination
  • K. Guo, J. Li, +6 authors Q. Zeng
  • Biology, Medicine
  • Science Translational Medicine
  • 7 September 2011
Antibody therapy can target intracellular proteins. The Tip of the Iceberg As Titanic fans know, the largest mass of an iceberg hides under the water’s surface; having knowledge of the buried bodyExpand
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Complete plastid genome of Larix potaninii var. macrocarpa, an endangered conifer endemic to China
Larix potaninii var. macrocarpa Y. W. Law. belongs to the genus Larix within family Pinaceae, is an endangered conifer species endemic to western China. In this study, the complete plastid genomeExpand
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Azoreductase-responsive Metal-organic Frameworks-based Nanodrug for Enhanced Cancer Therapy via Breaking Hypoxia-induced Chemoresistance.
The insufficient oxygen supply may cause hypoxia in solid tumor, which can lead to drug resistance and unsatisfactory chemotherapy effect. To address this issue, a new nanodrug is developed withExpand
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Highly selective imaging of lysosomal azoreductase under hypoxia using pH-regulated and target-activated fluorescent nanoprobes.
In this work, we propose a pH-regulated and target-activated fluorescent nanoprobe for highly selective monitoring of lysosomal azoreductase under hypoxia in living cells. We expect it will offer aExpand
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Whole plastid genome of Anemone taipaiensis (Ranunculaceae), an endemic herb plant in China
Abstract Anemone taipaiensis W. T. Wang is an endemic herb species in Shaanxi province (China). Here, we first characterized its whole plastid genome via pair-end sequencing method. The wholeExpand
The complete nucleotide sequence of chloroplast genome of Gentiana apiata (Gentianaceae), an endemic medicinal herb in China
Abstract Gentiana apiata N. E. Brown (Gentianaceae) is a perennial herb plant and only grows in Qinba Mountains in China. Here, we first characterized the complete nucleotide sequence of chloroplastExpand