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Commensal Viruses of Mosquitoes: Host Restriction, Transmission, and Interaction with Arboviral Pathogens
TLDR
It is shown that many ISVs are efficiently transmitted directly from the female mosquito to their progeny via infected eggs, and, moreover, that persistent infection of mosquito cell cultures or whole mosquitoes with ISVs can restrict subsequent infection, replication, and transmission of some mosquito-borne viral pathogens. Expand
A New Species of Mesonivirus from the Northern Territory, Australia
TLDR
The evolutionary distance between CASV and two of its closest relatives, Cavally and Hana viruses, along with its isolation from a different genus of mosquitoes captured on a separate continent indicate that CASV is a new species. Expand
West Nile Virus-Induced Activation of Mammalian Target of Rapamycin Complex 1 Supports Viral Growth and Viral Protein Expression
TLDR
The requirement for TORC1 function in support of WNV RNA translation is demonstrated and insight into the mechanisms underlying flaviviral RNA translation in mammalian cells is provided. Expand
Discovery of a novel iflavirus sequence in the eastern paralysis tick Ixodes holocyclus
TLDR
Next-generation sequencing of I. holocyclus salivary glands yielded a full-length genome sequence which phylogenetically groups with viruses classified in the Iflaviridae family and shares 45% amino acid similarity with its closest relative Bole hyalomma asiaticum virus 1. Expand
A new virus discovered by immunocapture of double‐stranded RNA, a rapid method for virus enrichment in metagenomic studies
TLDR
This study presents an alternative method to enrich dsRNA from plant extracts using anti‐dsRNA monoclonal antibodies in a pull‐down assay and believes that this new assay represents a significant opportunity to upscale virus ecology studies from environmental, primary industry and/or medical samples. Expand
Discovery and Characterisation of Castlerea Virus, a New Species of Negevirus Isolated in Australia
TLDR
Using a broad-spectrum virus screening assay based on the detection of double-stranded RNA and next-generation sequencing, a novel species of negevirus is detected, from Anopheles, Culex, and Aedes mosquitoes collected in 4 geographically separate regions of Australia. Expand
New genotypes of Liao ning virus (LNV) in Australia exhibit an insect-specific phenotype.
TLDR
High rates of virus detection in progeny reared from infected adult female mosquitoes, coupled with visualization of the virus within the ovarian follicles by immunohistochemistry, suggest that LNV is transmitted transovarially. Expand
Viral RNA Intermediates as Targets for Detection and Discovery of Novel and Emerging Mosquito-Borne Viruses
TLDR
Two monoclonal antibodies which show co-localised staining with proteins involved in viral RNA replication in immunofluorescence assay (IFA), suggesting specific reactivity to viral dsRNA are developed and incorporated into a high-throughput, economical ELISA-based screening system for the detection and discovery of viruses from mosquito populations. Expand
A New Orbivirus Isolated from Mosquitoes in North-Western Australia Shows Antigenic and Genetic Similarity to Corriparta Virus but Does Not Replicate in Vertebrate Cells
TLDR
A new virus is detected from mosquito populations of northern Australia that shares genomic sequence similarities to Corriparta virus and did not replicate in several vertebrate cell lines that were permissive to CORV, suggesting that PLV has evolved to have a very restricted host range, indicative of a mosquito-only life cycle. Expand
A newly discovered flavivirus in the yellow fever virus group displays restricted replication in vertebrates.
TLDR
The results indicate that BgV is an evolutionary divergent member of the YFV group of flaviviruses, and represents a novel system to study mechanisms of virus host-restriction and transmission. Expand
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