• Publications
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The role of histone deacetylase 7 (HDAC7) in cancer cell proliferation: regulation on c-Myc
  • Caihua Zhu, Qin Chen, +4 authors M. Geng
  • Biology, Medicine
  • Journal of Molecular Medicine
  • 1 March 2011
Histone deacetylases (HDACs) play fundamental roles in the epigenetic regulation of gene expression and contribute to the growth, differentiation, and apoptosis of cancer cells. Although HDACs areExpand
Synthesis and biological activity of novel shikonin analogues.
  • W. Wang, Mei Dai, +4 authors W. Duan
  • Chemistry, Medicine
  • Bioorganic & medicinal chemistry letters
  • 1 February 2009
A series of shikonin analogues with side chain variants have been synthesized and evaluated for antitumor activity. These novel analogues show a broad spectrum of in vitro cytotoxicity againstExpand
A series of alpha-heterocyclic carboxaldehyde thiosemicarbazones inhibit topoisomerase IIalpha catalytic activity.
  • He Huang, Qin Chen, +11 authors H. Liu
  • Chemistry, Medicine
  • Journal of medicinal chemistry
  • 30 March 2010
A series of novel thiosemicarbazone derivatives bearing condensed heterocyclic carboxaldehyde moieties were designed and synthesized. Among them, TSC24 exhibited broad antiproliferative activity in aExpand
Phospho-sulindac (OXT-922) inhibits the growth of human colon cancer cell lines: a redox/polyamine-dependent effect.
Non-steroidal anti-inflammatory drugs such as sulindac are promising chemoprevention agents against colon cancer, but their weak potency and side effects limit their use for both chemoprevention andExpand
Phosphosulindac (OXT‐328) Selectively Targets Breast Cancer Stem Cells In Vitro and in Human Breast Cancer Xenografts
Pharmacological targeting of breast cancer stem cells (CSCs) is highly promising for the treatment of breast cancer, as the small population of CSCs appears responsible for tumor initiation andExpand
MC-12, an Annexin A1-Based Peptide, Is Effective in the Treatment of Experimental Colitis
Annexin A1 (ANXA1) inhibits NF-κB, a key regulator of inflammation, the common pathophysiological mechanism of inflammatory bowel diseases (IBD). MC-12, an ANXA1-based tripeptide, suppresses NF-κBExpand
Epigenetic regulation of miR-375 in human colorectal cancer cells : a key role of DNA methylation
The methylation status of miR-375 promoter in human colorectal cancer (CRC) and the biological roles of dysregulated miR-375 in CRC cells remain unknown. Bioinformatics analysis combined withExpand