Cai-ying Ye

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OBJECTIVE To explore the potential anti-inflammatory and analgesic activities of carboxyamidotriazole (CAI). METHODS A variety of animal models, including the croton oil-induced ear edema, the cotton-induced granuloma, the rat adjuvant-induced arthritis, were used to evaluate anti-inflammatory effect of CAI. Vascular endothelial growth factor (VEGF)--or(More)
Carboxyamido-triazole (CAI), a voltage-independent calcium channel inhibitor, has been shown to be able to induce growth inhibition and apoptosis in cancer cells. In the present study, we demonstrate that CAI significantly inhibits proliferation of cultured MCF-7 human breast cancer cells in a dose-dependent manner with an IC(50) of approximately 26 microM.(More)
OBJECTIVE To determine the affinity of new opioid receptor ligands to cloned mu opioid receptors stably expressed in CHO cell. METHODS The binding characteristics of the opioid ligand [3H] diprenorphine (3H-dip) were studied by cellular biological techniques and radioligands binding in cloned mu opioid receptors stably expressed in CHO cells in saturation(More)
Cancer cachexia is a complex disorder characterized by inflammatory responses, and it is associated with poor performance status and high mortality rate of cancer patients. Carboxyamidotriazole (CAI), a noncytotoxic chemotherapy agent, shows anti-inflammatory features in the treatment of many diseases. Here, we investigated the preventive and therapeutic(More)
OBJECTIVE To investigate the dual effects by the delta opioid receptor agonists DPDPE on the delayed rectified potassium channels in NG108-15 cells. METHODS A series of outward currents were evoked in NG108-15 cells by depolarizing voltage from -50 mV to +80 mV at holding potential of -90 mV. These currents were delayed rectified potassium currents.(More)
OBJECTIVE To study the effect of carboxyamidotriazole (CAI) on adjuvant arthritis (AA) in rats. METHODS The rats were randomly divided into normal group,two vehicle groups (polyethylene glycol 400 control and normal sodium control group), CAI-treated groups (10, 20, and 40 mg/kg) and positive control dexamethasone group. Freund's completed adjuvant was(More)
  • Cai-ying Ye
  • Zhongguo yi xue ke xue yuan xue bao. Acta…
  • 1991
A-alpha-CAM is an irreversible partial agonist of opiate receptors. Its binding to opioid receptors from P2 membrane preparations of rat brain and its effect on isolated tissues (GPI, MVD, RVD and RbVD) could not be washed away, indicating the irreversible nature of its binding. A-alpha-CAM inhibited the electrically elicited contraction of GPI, a pure(More)
OBJECTIVE To observe the role of G protein in the dual regulation of opioid receptor agonist on the delayed rectified potassium channels. METHODS Using whole-cell patch-clamp techniques applied to NG108-15 cells, investigate the effect of opioid receptor agonist on the delayed rectified potassium channels by administration of(More)
Aim:The selective serotonin (5-HT) and norepinephrine (NE) reuptake inhibitors (SNRIs) are commonly used for the treatment of neuropathic pain and fibromyalgia. Ammoxetine ((±)-3-(benzo[d] [1,3]dioxol-4-yloxy)-N-methyl-3-(thiophen-2-yl)propan-1-amine) has been identified as a novel potent SNRI. In this study, we evaluated the acute analgesic properties of(More)
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