Infection Exposure Promotes ETV6-RUNX1 Precursor B-cell Leukemia via Impaired H3K4 Demethylases.
- G. Rodríguez-Hernández, J. Hauer, A. Borkhardt
- BiologyCancer Research
- 2017
The genetic basis for clonal evolution of an ETV6-RUNX1 preleukemic clone to pB-ALL after infection exposure is explained and the possibility of novel therapeutic approaches is offered.
Next-generation-sequencing of recurrent childhood high hyperdiploid acute lymphoblastic leukemia reveals mutations typically associated with high risk patients.
- Cai Chen, C. Bartenhagen, U. Fischer
- BiologyLeukemia research : a Forum for Studies on…
- 1 September 2015
Next‐generation‐sequencing‐based risk stratification and identification of new genes involved in structural and sequence variations in near haploid lymphoblastic leukemia
- Cai Chen, C. Bartenhagen, A. Borkhardt
- BiologyGenes, Chromosomes and Cancer
- 1 June 2013
NGS showed that all disomic chromosomes of MHH‐CALL‐2, but none of the patients, were of uniparental origin, thus reliably discriminating these subtypes, and revealed homozygous non‐synonymous coding mutations predicted to be deleterious for the protein function of 63 genes, among them known cancer‐associated genes.
Infection as a cause of childhood leukemia: virus detection employing whole genome sequencing
- C. Bartenhagen, U. Fischer, A. Borkhardt
- BiologyHaematologica
- 1 May 2017
Evidence from epidemiological studies strongly suggests that the increased leukemia rate is likely related to an abnormal immune response to acute lymphoblastic leukemia.
A novel approach to detect resistance mechanisms reveals FGR as a factor mediating HDAC inhibitor SAHA resistance in B‐cell lymphoma
- M. Joosten, S. Ginzel, V. Seitz
- Medicine, BiologyMolecular Oncology
- 1 October 2016
Inhibition of 32Dp210 cells harboring T315I mutation by a novel derivative of emodin correlates with down-regulation of BCR-ABL and its downstream signaling pathways
- Jing Li, Yingyu Chen, Jianda Hu
- Biology, ChemistryJournal of Cancer Research and Clinical Oncology
- 1 February 2015
This study indicated that E35 might be a potential antileukemia agent against IM resistance in CML.
Chromothripsis-Mediated Structural Variations and Clonal Evolution In Recurrent Childhood High Hyperdiploid Acute Lymphoblastic Leukemia
- Cai Chen, C. Bartenhagen, U. Fischer
- Biology
- 15 November 2013
State-of-the-art whole-genome next-generation-sequencing was applied to analyze structural variations in six pediatric patients with recurrent HeH-ALL to identify fragile genomic sites prone to chromothripsis.
Somatic Structural Variations in Pediatric High Hyperdiploid Acute Lymphoblastic Leukemia Revealed by Paired-End Parallel Sequencing
- Cai Chen, C. Bartenhagen, A. Borkhardt
- Biology
- 18 November 2011
Paired-end sequencing of leukemia samples and matched non-tumor materials provides a robust tool for the discovery of genome-wide structural rearrangements and suggests a common origin and a close relationship of the leukemic clones at diagnosis and relapse.
[Clinical Features and Prognosis of 35 Children with Burkitt Lymphoma/Leukemia].
- Yongzhi Zheng, S. Le, Jian-da Hu
- MedicineZhongguo shi yan xue ye xue za zhi
- 1 August 2019
The childhood Buruitts lymphoma/leukemia is more freguently seen in males and school-age children, Advanced stage, bone marrow and contral nervous system infitration are common at the first visit to doctor, moreover the Burkitt's lymphomas/leykemia present repid progression and dangerous feature.
Long-term outcome of tyrosine kinase inhibitor treatment in children and adolescents with newly diagnosed chronic myeloid leukemia in chronic phase
- Yongzhi Zheng, Jian Li, Cai Chen, Hao Zheng, D. Fu, Jian-da Hu
- Medicine, BiologyChinese Medical Journal
- 22 July 2021
This report retrospectively analyzed the long-term follow-up results of 58 pediatric patients with CML-CP treated with IM as first-line treatment and 2G-TKIs as second-line therapy in a single South China center.
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