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Introduction The actions of glyceryl trinitrate (GTN) are the result of its bioconversion into NO; NO increases the intracellular concentration of cyclic guanosine monophosphate (cGMP), which produces pain modulation in the central and peripheral nervous system (Griesberger et al. 2011,). In addition, GTN administration is considered a reliable experimental(More)
Introduction Cobalt chloride (CoCl2) is a widely used hypoxia-mimetic; preconditioning with cobalt has been reported to exert protection against ischemic injury as well as decreasing pro-inflammatory cytokine levels (Shukla et al. 2011,). Exposure to moderate hypoxia may lead to neurological phenomena such as paraesthesia, numbness or pain, possibly as a(More)
Methods Sixteen Swiss male mice were divided into 2 groups: control group (n=8) and MB group (n=8); both groups received daily injections, for 14 days, either with saline 20 Î1⁄4l i.p. (control group) or with MB 5 mg/kg b.w. i.p (MB group). Nociceptive tests (tail flick and hot plate) as well as mechanical and thermal withdrawal thresholds were measured(More)
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