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The electromyogram of the circular muscle layer of the cat colon was studied in vitro in superfused strips of muscle. Records exhibited electrical slow waves and migrating spike bursts, as described previously. Both the neurotoxin, tetrodotoxin, and the local anesthetic lidocaine, (P less than 0.05) prolonged the duration of migrating spike bursts, but(More)
SUMMARY During therapy with an antineoplastic agent, hydroxyurea, early abrupt megaloblastic changes were evident in the marrow. Correlative biochemical studies suggested that the megaloblasto-sis resulted from an abrupt decrease in reductive conversion of ribotide to deoxyribotide and that hydroxyurea induces defec tive reductive conversion. Evidence for(More)
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