CJM van Noesel

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BACKGROUND Constitutive Wnt activation is essential for colorectal cancer (CRC) initiation but also underlies the cancer stem cell phenotype, metastasis and chemosensitivity. Importantly Wnt activity is still modulated as evidenced by higher Wnt activity at the invasive front of clonal tumours termed the β-catenin paradox. SMAD4 and p53 mutation status and(More)
AIMS To describe the evolution of proficiency testing for molecular diagnostic pathology with respect to determining unambiguously the patient identity of tissue samples by microsatellite analysis. METHOD Four rounds of quality control exchanges of samples from different patients were sent with the purpose of identifying the correct origin of these(More)
Colorectal cancer (CRC) is a heterogeneous disease posing a challenge for accurate classification and treatment of this malignancy. There is no common genetic molecular feature that would allow for the identification of patients at risk for developing recurrences and thus selecting patients who would benefit from more stringent therapies still poses a major(More)
Follicular lymphoma (FL) is one of the most common B-cell non-Hodgkin's lymphomas. The initiating genetic event found in B90% of FL is the t(14;18), causing constitutive expression of the antiapoptotic BCL-2 protein. The exact secondary alterations leading to full FL development are still poorly defined. In this review, we address (i) the genetic pathways(More)
Hyperplastic polyposis syndrome (HPS) is a heterogeneous condition involving colorectal serrated polyps and is associated with an increased colorectal cancer (CRC) risk. We evaluated the clinicopathological features of HPS patients and their first-degree relatives. Previously published case series report CRC at clinical presentation in up to 50% of HPS(More)
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