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Sir, Phosphatase, homologue to tensin (PTEN), is a tumour suppressor protein that regulates the PI3K/AKT signalling pathway. Loss of PTEN expression results in overactivation of the Akt pathway and confers resistance to inhibitors of the epidermal growth factor receptor (EGFR). Recently, four clinical studies have evaluated the association between PTEN(More)
The frequency and poor prognosis of patients with metastatic colorectal cancer (mCRC) emphasizes the requirement for improved biomarkers for use in the treatment and prognosis of mCRC. In the present study, somatic variants in exonic regions of key cancer genes were identified in mCRC patients. Formalin‑fixed, paraffin‑embedded tissues obtained by biopsy of(More)
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