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Genotoxicity of mixtures of glyphosate and atrazine and their environmental transformation products before and after photoactivation.
TLDR
This study established that enhanced cytogenetic activities could be observed in pesticide mixtures containing glyphosate, atrazine, and their degradation products AMPA and DEA, and highlighted the importance of cocktail effects in environmental matrices. Expand
Antimalarial activity of four plants used in traditional medicine in Mali
TLDR
Evidence is presented that the alkaloids contained in chloroform extracts and ursolic acid, purified from the hydromethanol extract of M. inermis induced a significant decrease of parasite proliferation, however, aqueous extracts did not show high antimalarial activity. Expand
Assessment of the genotoxicity of three cryoprotectants used for human oocyte vitrification: dimethyl sulfoxide, ethylene glycol and propylene glycol.
TLDR
High concentrations of EG and PrOH could induce in vitro chromosomal damage in eukaryotic cells, and showed that high concentrations of these cryoprotectants may induce long-term toxic effects on cells. Expand
In vitro activity of the beta-carboline alkaloids harmane, harmine, and harmaline toward parasites of the species Leishmania infantum.
TLDR
Harmaline exerted a strong antileishmanial activity toward the intracellular amastigote form of the parasite, which was shown to partly result from the capacity of the molecule to prevent parasite internalization within macrophages by inhibiting Leishmania PKC activity. Expand
Identification of disinfection by-products in freshwater and seawater swimming pools and evaluation of genotoxicity.
TLDR
The results of Ames test showed higher mutagenicity in the freshwater pool as a consequence of its considerably higher DBP contents in comparison to the tested seawater pool, and higher genotoxic properties of water samples of the freshwater pools through the Salmonella assay. Expand
Evaluation of the genotoxicity of river sediments from industrialized and unaffected areas using a battery of short‐term bioassays
TLDR
The genotoxicity ranking determined by the comet assay + S9 matched the ranking of total and carcinogenic PAH concentrations, and this assay was found to be the most sensitive. Expand
Synergistic in vitro antimalarial activity of plant extracts used as traditional herbal remedies in Mali
TLDR
Three combinations demonstrate a strong, synergistic, inhibitory effect on in vitro plasmodial development and are devoid of cytotoxicity towards human cells, which justify their use in association in traditional medicine. Expand
Antimalarial activity of extracts and alkaloids isolated from six plants used in traditional medicine in Mali and Sao Tome
TLDR
Two alkaloids isolated from the active extract of Guiera senegalensis, harman and tetrahydroharman, showed antimalarial activity and displayed low toxicity against THP1. Expand
Genotoxicity assessment of mouse oocytes by comet assay before vitrification and after warming with three vitrification protocols.
TLDR
Vitrification protocols containing PrOH induced significant DNA damage on mouse oocytes, both before cooling and after warming, therefore, for the moment, vitrification techniques without PrOH are preferred while the authors await more studies on PrOH toxicity and long-term evaluation. Expand
Photo-inducible cytotoxic and clastogenic activities of 3,6-di-substituted acridines obtained by acylation of proflavine.
TLDR
The results suggested that the two derivatives of 3,6-di-substituted acridines could be considered as interesting candidates for anticancer chemotherapy and hypothesized that the presence of 1,1-dimethylethyl substituents was responsible for a strong nonclastogenic cytotoxicity. Expand
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