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Pseudomonas aeruginosa: all roads lead to resistance.
D-enantiomeric peptides that eradicate wild-type and multidrug-resistant biofilms and protect against lethal Pseudomonas aeruginosa infections.
Broad-Spectrum Anti-biofilm Peptide That Targets a Cellular Stress Response
- C. de la Fuente-Nunez, F. Reffuveille, E. Haney, S. Straus, R. Hancock
- BiologyPLoS pathogens
- 1 May 2014
NMR and chromatography studies showed that the peptide acted on cells to cause degradation of (p)ppGpp within 30 minutes, and in vitro directly interacted with ppGpp, suggesting a new approach against biofilm-related drug resistance.
The value of antimicrobial peptides in the age of resistance.
Inhibition of Bacterial Biofilm Formation and Swarming Motility by a Small Synthetic Cationic Peptide
- C. de la Fuente-Nunez, V. Korolik, R. Hancock
- BiologyAntimicrobial Agents and Chemotherapy
- 21 February 2012
Peptide 1037 shows promise as a potential therapeutic agent against chronic, recurrent biofilm infections caused by a variety of bacteria.
Bacterial biofilm development as a multicellular adaptation: antibiotic resistance and new therapeutic strategies.
The next generation of antimicrobial peptides (AMPs) as molecular therapeutic tools for the treatment of diseases with social and economic impacts
An anti-infective synthetic peptide with dual antimicrobial and immunomodulatory activities
The peptide presented here directly kills bacteria and further helps resolve infections through its immune modulatory properties, and represents a new approach to treat antibiotic-resistant infections.
3D Printing of Living Responsive Materials and Devices
A new method and material system capable of 3D-printing hydrogel inks with programed bacterial cells as responsive components into large-scale, high-resolution living materials, where the cells can communicate and process signals in a programmable manner are reported.
A Broad-Spectrum Antibiofilm Peptide Enhances Antibiotic Action against Bacterial Biofilms
- F. Reffuveille, C. de la Fuente-Nunez, Sarah C. Mansour, R. Hancock
- Biology, MedicineAntimicrobial Agents and Chemotherapy
- 30 June 2014
Treatment with the peptide represents a novel strategy to potentiate antibiotic activity against biofilms formed by multidrug-resistant pathogens.