Differences between males and females in rates of serotonin synthesis in human brain.
- S. Nishizawa, C. Benkelfat, M. Diksic
- Biology, PsychologyProceedings of the National Academy of Sciences…
- 13 May 1997
The mean rate of synthesis in normal males was found to be 52% higher than in normal females; this marked difference may be a factor relevant to the lower incidence of major unipolar depression in males.
Modifications of the Serotonin System by Antidepressant Treatments: Implications for the Therapeutic Response in Major Depression
- P. Blier, C. de Montigny, Y. Chaput
- Biology, PsychologyJournal of Clinical Psychopharmacology
- 1 December 1987
Results of electrophysiological single-cell recording studies suggest that most, if not all, types of antidepressant treatments increase 5-hydroxytryptamine (5-HT) neurotransmission. Tricyclic…
Long-Term Antidepressant Treatments Result in a Tonic Activation of Forebrain 5-HT1A Receptors
- N. Haddjeri, P. Blier, C. de Montigny
- Biology, PsychologyJournal of Neuroscience
- 1 December 1998
Data indicate that such antidepressant treatments, acting on entirely different primary targets, might alleviate depression by enhancing the tonic activation of forebrain postsynaptic 5-HT1Areceptors.
Current advances and trends in the treatment of depression.
- P. Blier, C. de Montigny
- PsychologyTIPS - Trends in Pharmacological Sciences
- 1 July 1994
Rhythmic activity induced by harmaline in the olivo-cerebello-bulbar system of the cat.
- C. de Montigny, Y. Lamarre
- BiologyBrain Research
- 13 April 1973
A role for the serotonin system in the mechanism of action of antidepressant treatments: preclinical evidence.
- P. Blier, C. de Montigny, Y. Chaput
- Biology, PsychologyJournal of Clinical Psychiatry
- 1 April 1990
The electrophysiologic assessment of the action of different types of antidepressant treatments on the serotonin system revealed as a common effect an enhancement of 5-HT neurotransmission, albeit each treatment achieved this result via a different mechanism.
Effect of Pindolol on the Function of Pre- and Postsynaptic 5-HT1A Receptors: In Vivo Microdialysis and Electrophysiological Studies in the Rat Brain
- L. Romero, N. Bel, F. Artigas, C. de Montigny, P. Blier
- Biology, ChemistryNeuropsychopharmacology
- 1 October 1996
Potentiation of neuronal NMDA response induced by dehydroepiandrosterone and its suppression by progesterone: effects mediated via sigma receptors
- R. Bergeron, C. de Montigny, G. Debonnel
- BiologyJournal of Neuroscience
- 1 February 1996
The results suggest that some neuroactive steroids modulate the NMDA response via sigma receptors through the potentiation of dehydroepiandrosterone.
Presynaptic and postsynaptic modifications of the serotonin system by long-term administration of antidepressant treatments. An in vivo electrophysiologic study in the rat.
- Y. Chaput, C. de Montigny, P. Blier
- Biology, PsychologyNeuropsychopharmacology
- 1 December 1991
The present data confirm and extend those of previous electrophysiologic studies showing that an enhanced 5-HT synaptic transmission is a common end result of long-term administration of various types of antidepressant treatments and suggest that the mechanisms underlying this enhanced synaptic transmission differ according to the type of treatment administered.
Modulation of the firing activity of noradrenergic neurones in the rat locus coeruleus by the 5‐hydroxtryptamine system
- N. Haddjeri, C. de Montigny, P. Blier
- Biology, ChemistryBritish Journal of Pharmacology
- 1 February 1997
The data support the notion that the 5‐HT system tonically modulates NA neurotransmission since the lesion of 5‐ HT neurones enhanced the LC NA neurones firing activity and the suppressant effect of WAY 100635 on the firing activity ofNA neurones was abolished by this lesion.
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