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Differences between males and females in rates of serotonin synthesis in human brain.
The mean rate of synthesis in normal males was found to be 52% higher than in normal females; this marked difference may be a factor relevant to the lower incidence of major unipolar depression in males. Expand
Modifications of the Serotonin System by Antidepressant Treatments: Implications for the Therapeutic Response in Major Depression
Results of electrophysiological single-cell recording studies suggest that most, if not all, types of antidepressant treatments increase 5-hydroxytryptamine (5-HT) neurotransmission. TricyclicExpand
Long-Term Antidepressant Treatments Result in a Tonic Activation of Forebrain 5-HT1A Receptors
Data indicate that such antidepressant treatments, acting on entirely different primary targets, might alleviate depression by enhancing the tonic activation of forebrain postsynaptic 5-HT1Areceptors. Expand
Current advances and trends in the treatment of depression.
A better understanding of the neurobiological basis for the delayed onset of action of antidepressant treatments has led to the elaboration of strategies that could accelerate the antidepressant response. Expand
Rhythmic activity induced by harmaline in the olivo-cerebello-bulbar system of the cat.
From simultaneous recordings along the olivo-cerebello-bulbar system, it appears very likely that the bulbar reticular and vestibular rhythmic activity is primarily the consequence of the periodic interruption of fastigial cells firing by the rhythmic climbing fiber responses. Expand
Effect of Pindolol on the Function of Pre- and Postsynaptic 5-HT1A Receptors: In Vivo Microdialysis and Electrophysiological Studies in the Rat Brain
Results indicate that (−)pindolol can potentiate the effects of an SSRI on extracellular 5-HT concentration by preventing the activation of somatodendritic 5- HT1A autoreceptors resulting from the blockade of the5-HT transporter in the raphe. Expand
Potentiation of neuronal NMDA response induced by dehydroepiandrosterone and its suppression by progesterone: effects mediated via sigma receptors
The results suggest that some neuroactive steroids modulate the NMDA response via sigma receptors through the potentiation of dehydroepiandrosterone. Expand
A role for the serotonin system in the mechanism of action of antidepressant treatments: preclinical evidence.
The electrophysiologic assessment of the action of different types of antidepressant treatments on the serotonin system revealed as a common effect an enhancement of 5-HT neurotransmission, albeit each treatment achieved this result via a different mechanism. Expand
Presynaptic and postsynaptic modifications of the serotonin system by long-term administration of antidepressant treatments. An in vivo electrophysiologic study in the rat.
The present data confirm and extend those of previous electrophysiologic studies showing that an enhanced 5-HT synaptic transmission is a common end result of long-term administration of various types of antidepressant treatments and suggest that the mechanisms underlying this enhanced synaptic transmission differ according to the type of treatment administered. Expand