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A SARS-CoV-2 Protein Interaction Map Reveals Targets for Drug-Repurposing
A human–SARS-CoV-2 protein interaction map highlights cellular processes that are hijacked by the virus and that can be targeted by existing drugs, including inhibitors of mRNA translation and predicted regulators of the sigma receptors.
Genome sequencing and analysis of the versatile cell factory Aspergillus niger CBS 513.88
The filamentous fungus Aspergillus niger is widely exploited by the fermentation industry for the production of enzymes and organic acids, particularly citric acid, and the sequenced genome revealed a large number of major facilitator superfamily transporters and fungal zinc binuclear cluster transcription factors.
A SARS-CoV-2-Human Protein-Protein Interaction Map Reveals Drug Targets and Potential Drug-Repurposing
The identification of host dependency factors mediating virus infection may provide key insights into effective molecular targets for developing broadly acting antiviral therapeutics against SARS-CoV-2 and other deadly coronavirus strains.
Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae
The aspergilli comprise a diverse group of filamentous fungi spanning over 200 million years of evolution, and a comparative study with Aspergillus fumigatus and As pergillus oryzae, used in the production of sake, miso and soy sauce, provides new insight into eukaryotic genome evolution and gene regulation.
NRG1 represses yeast–hypha morphogenesis and hypha‐specific gene expression in Candida albicans
CaNrg1 is a transcriptional repressor that appears to target CaTup1 to a distinct set of virulence‐related functions, including yeast–hypha morphogenesis.
Molecular Phylogenetics of Candida albicans
Analysis of data on multilocus sequence typing, ABC typing, mating type-like locus (MAT) status, and antifungal susceptibility for a panel of 1,391 Candida albicans isolates suggested that isolates had mixed evolutionary histories resembling those of a sexually reproducing species.
Candida albicans Biofilms: a Developmental State Associated With Specific and Stable Gene Expression Patterns
- S. Garcia-Sanchez, S. Aubert, I. Iraqui, G. Janbon, J. Ghigo, C. d’Enfert
- BiologyEukaryotic Cell
- 1 April 2004
Biofilm and planktonic cultures produced under different conditions of nutrient flow, aerobiosis, or glucose concentration were compared by overall gene expression correlation, indicating that biofilm populations formed in different environments display very similar and specific transcript profiles.
Selection of multiple disruption events in Aspergillus fumigatus using the orotidine-5′-decarboxylase gene, pyrG, as a unique transformation marker
- C. d’Enfert
- BiologyCurrent Genetics
- 1 June 1996
A 8.6-kb disruption cassette consisting of the Aspergillus niger pyrG gene flanked by a direct repeat that encodes the neomycin phosphotransferase of transposon Tn5 was constructed to disrupt another gene.
A rapid method for efficient gene replacement in the filamentous fungus Aspergillus nidulans.
A two-step technology takes advantage of an Escherichia coli strain expressing the phage lambda Red functions and enables the rapid establishment of mutant strains carrying gene knock-outs with efficiencies >50%.
Transcript profiling in Candida albicans reveals new cellular functions for the transcriptional repressors CaTup1, CaMig1 and CaNrg1
The targets of CaMig1 and CaNrg1 repression, and phenotypic analyses of nrg1/nrg1 and mig1/mig1 mutants, indicate that these factors play differential roles in the regulation of metabolism, cellular morphogenesis and stress responses.