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Mammalian Sweet Taste Receptors
The sense of taste provides animals with valuable information about the quality and nutritional value of food. Previously, we identified a large family of mammalian taste receptors involved in bitterExpand
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The Receptors for Mammalian Sweet and Umami Taste
Sweet and umami (the taste of monosodium glutamate) are the main attractive taste modalities in humans. T1Rs are candidate mammalian taste receptors that combine to assemble two heteromericExpand
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T2Rs Function as Bitter Taste Receptors
Bitter taste perception provides animals with critical protection against ingestion of poisonous compounds. In the accompanying paper, we report the characterization of a large family of putativeExpand
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Coding of Sweet, Bitter, and Umami Tastes Different Receptor Cells Sharing Similar Signaling Pathways
Mammals can taste a wide repertoire of chemosensory stimuli. Two unrelated families of receptors (T1Rs and T2Rs) mediate responses to sweet, amino acids, and bitter compounds. Here, we demonstrateExpand
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A Novel Family of Mammalian Taste Receptors
In mammals, taste perception is a major mode of sensory input. We have identified a novel family of 40-80 human and rodent G protein-coupled receptors expressed in subsets of taste receptor cells ofExpand
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A Chemosensory Gene Family Encoding Candidate Gustatory and Olfactory Receptors in Drosophila
A novel family of candidate gustatory receptors (GRs) was recently identified in searches of the Drosophila genome. We have performed in situ hybridization and transgene experiments that revealExpand
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A Drosophila mechanosensory transduction channel.
Mechanosensory transduction underlies a wide range of senses, including proprioception, touch, balance, and hearing. The pivotal element of these senses is a mechanically gated ion channel thatExpand
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Genetic dissection of mechanosensory transduction: Mechanoreception-defective mutations of drosophila
To identify genes involved in mechanotransduction, Drosophila larvae were screened for X-linked mutations affecting a behavioral response to touch. Many mutations that caused nondevelopmental defectsExpand
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Putative Mammalian Taste Receptors A Class of Taste-Specific GPCRs with Distinct Topographic Selectivity
Taste represents a major form of sensory input in the animal kingdom. In mammals, taste perception begins with the recognition of tastant molecules by unknown membrane receptors localized on theExpand
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The Drosophila Light-Activated Conductance Is Composed of the Two Channels TRP and TRPL
SUMMARY Drosophila phototransduction is a G protein-coupled, calcium-regulated signaling cascade that serves as a model system for the dissection of phospholipase C (PLC) signaling in vivo. TheExpand
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