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Regulation of cardiac excitation–contraction coupling by action potential repolarization: role of the transient outward potassium current (Ito)
The cardiac action potential (AP) is critical for initiating and coordinating myocyte contraction. In particular, the early repolarization period of the AP (phase 1) strongly influences the timeExpand
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The molecular physiology of the cardiac transient outward potassium current (I(to)) in normal and diseased myocardium.
G. Y. Oudit, Z. Kassiri, R. Sah, R. J. Ramirez, C. Zobel and P. H. Backx. The Molecular Physiology of the Cardiac Transient Outward Potassium Current (I(to)) in Normal and Diseased Myocardium.Expand
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Ouabain-Like Compound Changes Rapidly on Physical Exercise in Humans and Dogs: Effects of &bgr;-Blockade and Angiotensin-Converting Enzyme Inhibition
Ouabain, an inhibitor of the sodium pump, has been identified as a constituent of bovine adrenal glands. We were interested whether the release of this cardiotonic steroid is stimulated by physicalExpand
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Molecular dissection of the inward rectifier potassium current (IK1) in rabbit cardiomyocytes: evidence for heteromeric co‐assembly of Kir2.1 and Kir2.2
Cardiac inward rectifier K+ currents (IK1) play an important role in maintaining resting membrane potential and contribute to late phase repolarization. Members of the Kir2.x channel family appear toExpand
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Losartan prevents stretch-induced electrical remodeling in cultured atrial neonatal myocytes.
Atrial fibrillation (AF) is the most frequent arrhythmia found in clinical practice. In recent studies, a decrease in the development or recurrence of AF was found in hypertensive patients treatedExpand
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Reduction of Ito Causes Hypertrophy in Neonatal Rat Ventricular Myocytes
Prolonged action potential duration (APD) and decreased transient outward K+ current (Ito) as a result of decreased expression of Kv4.2 and Kv4.3 genes are commonly observed in heart disease. WeExpand
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Mild therapeutic hypothermia in cardiogenic shock syndrome*
Objective:Mortality in patients with cardiogenic shock after out-of-hospital cardiac arrest remains high despite advances in resuscitation and early revascularization strategies. Recent studiesExpand
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Prevention of Hypertrophy by Overexpression of Kv4.2 in Cultured Neonatal Cardiomyocytes
Background—Prolonged action potentials (APs) and decreased transient outward K+ currents (Ito) are consistent findings in hypertrophic myocardium. However, the connection of these changes withExpand
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A simple device to apply equibiaxial strain to cells cultured on flexible membranes.
The biomechanical environment to which cells are exposed is important to their normal growth, development, interaction, and function. Accordingly, there has been much interest in studying the role ofExpand
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Changes in Neuron-Specific Enolase are More Suitable Than Its Absolute Serum Levels for the Prediction of Neurologic Outcome in Hypothermia-Treated Patients with Out-of-Hospital Cardiac Arrest
BackgroundTo determine neurologic outcome in patients with out-of-hospital cardiac arrest (OHCA) and treatment with mild therapeutic hypothermia (MTH).MethodsSeventy-three consecutive OHCA patientsExpand
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