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The evolution of insecticide resistance in the peach potato aphid, Myzus persicae.
TLDR
The biochemical and molecular mechanisms underlying resistance in M. persicae are summarized and the insights study of this topic has provided on how resistance evolves, the selectivity of insecticides, and the link between resistance and host plant adaptation are summarized. Expand
Resistance to diamide insecticides in diamondback moth, Plutella xylostella (Lepidoptera: Plutellidae) is associated with a mutation in the membrane-spanning domain of the ryanodine receptor.
TLDR
A region of the gene encoding the proposed diamide binding site of the RyR from P. xylostella strongly suggests a causal association with diamide resistance, and designed a pyrosequencing-based diagnostic assay for resistance monitoring purposes that can be used to detect the G4946E mutation in field-collected samples of diamondback moth. Expand
Gene amplification and microsatellite polymorphism underlie a recent insect host shift
TLDR
It is concluded that the mutations leading to overexpression of CYP6CY3 were a prerequisite for the host shift of M. persicae to tobacco and that gene amplification and microsatellite polymorphism are evolutionary drivers in insect host adaptation. Expand
Unravelling the Molecular Determinants of Bee Sensitivity to Neonicotinoid Insecticides
TLDR
The results demonstrate that bee pollinators are equipped with biochemical defense systems that define their sensitivity to insecticides and this knowledge can be leveraged to safeguard bee health. Expand
A CRISPR/Cas9 mediated point mutation in the alpha 6 subunit of the nicotinic acetylcholine receptor confers resistance to spinosad in Drosophila melanogaster
TLDR
This study uses the CRISPR/Cas9 gene editing platform to introduce the G275E mutation into the nAChR α6 subunit of Drosophila melanogaster, and demonstrates the functional role of this amino acid substitution in resistance to spinosad. Expand
Molecular and functional characterization of CYP6BQ23, a cytochrome P450 conferring resistance to pyrethroids in European populations of pollen beetle, Meligethes aeneus.
TLDR
A single P450 gene, CYP6BQ23, which is significantly and highly overexpressed in adults and larvae of pyrethroid resistant strains compared to susceptible strains is revealed and results strongly suggest that the overexpression of CYP 6BQ 23 is the primary mechanism conferring pyrethoid resistance in pollen beetle populations throughout much of Europe. Expand
A de novo transcriptome of European pollen beetle populations and its analysis, with special reference to insecticide action and resistance
TLDR
The results provide new insights into the important genes associated with pyrethroid resistance in M. aeneus and a comprehensive EST resource is provided for future studies on insecticide modes of action and resistance mechanisms in pollen beetle. Expand
Insecticide resistance mediated by an exon skipping event
TLDR
It is shown that spinosad resistance in the tomato leaf miner, Tuta absoluta is associated with aberrant regulation of splicing of Taα6 resulting in a novel form of insecticide resistance mediated by exon skipping. Expand
Genomic insights into neonicotinoid sensitivity in the solitary bee Osmia bicornis
TLDR
The genome of the red mason bee, Osmia bicornis, is sequenced and reveals conserved detoxification pathways in model solitary and eusocial bees despite key differences in the evolution of specific pesticide-metabolising enzymes in the two species groups. Expand
Target-site resistance to pyrethroid insecticides in German populations of the cabbage stem flea beetle, Psylliodes chrysocephala L. (Coleoptera: Chrysomelidae).
TLDR
Investigating the presence of polymorphisms in the para-type voltage-gated sodium channel gene of P. chrysocephala found a single nucleotide polymorphism resulting in an L1014F (kdr) mutation within domain IIS6 of the channel protein, known as one of the chief pyrethroid target-site resistance mechanisms in several other pest insects. Expand
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