• Publications
  • Influence
CEACAM1 regulates TIM-3-mediated tolerance and exhaustion
T-cell immunoglobulin domain and mucin domain-3 (TIM-3, also known as HAVCR2) is an activation-induced inhibitory molecule involved in tolerance and shown to induce T-cell exhaustion in chronic viralExpand
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Bat3 promotes T cell responses and autoimmunity by repressing Tim-3–mediated cell death and exhaustion
T cell immunoglobulin and mucin domain–containing 3 (Tim-3) is an inhibitory receptor that is expressed on exhausted T cells during infection with HIV-1 and hepatitis C virus. By contrast, Tim-3Expand
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Phosphotyrosine-Dependent Coupling of Tim-3 to T-Cell Receptor Signaling Pathways
ABSTRACT The transmembrane protein Tim-3 has been shown to negatively regulate T-cell-dependent immune responses and was recently demonstrated to be associated with the phenomenon of immuneExpand
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CD5L/AIM Regulates Lipid Biosynthesis and Restrains Th17 Cell Pathogenicity
Th17 cells play a critical role in host defense against extracellular pathogens and tissue homeostasis but can induce autoimmunity. The mechanisms implicated in balancing "pathogenic" andExpand
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Emission factors of particulate matter and elemental carbon for crop residues and coals burned in typical household stoves in China.
Both particulate matter (PM) and black carbon (BC) impact climate change and human health. Uncertainties in emission inventories of PM and BC are partially due to large variation of measured emissionExpand
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Nonlinear sorting, curvature generation, and crowding of endophilin N-BAR on tubular membranes.
The curvature of biological membranes is controlled by membrane-bound proteins. For example, during endocytosis, the sorting of membrane components, vesicle budding, and fission from the plasmaExpand
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Coupling between endocytosis and sphingosine kinase I recruitment
Genetic studies have suggested a functional link between cholesterol/sphingolipid metabolism and endocytic membrane traffic. Here we show that perturbing the cholesterol/sphingomyelin balance in theExpand
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Melatonin Contributes to the Seasonality of Multiple Sclerosis Relapses
Seasonal changes in disease activity have been observed in multiple sclerosis, an autoimmune disorder that affects the CNS. These epidemiological observations suggest that environmental factorsExpand
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Antimony speciation and contamination of waters in the Xikuangshan antimony mining and smelting area, China
  • Faye Liu, X. Le, +5 authors C. Zhu
  • Chemistry, Medicine
  • Environmental geochemistry and health
  • 26 January 2010
Water samples from Xikuangshan (China), the world largest antimony (Sb) mine with a Sb mining and smelting history of more than 200 years, were analyzed. These water samples ranged from stream waterExpand
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Differential engagement of Tim-1 during activation can positively or negatively costimulate T cell expansion and effector function
It has been suggested that T cell immunoglobulin mucin (Tim)-1 expressed on T cells serves to positively costimulate T cell responses. However, crosslinking of Tim-1 by its ligand Tim-4 resulted inExpand
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