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Cryo-EM structure of TRPC5 at 2.8-Å resolution reveals unique and conserved structural elements essential for channel function
This high-resolution structure of mTRPC5, combined with electrophysiology and mutagenesis, provides insight into the lipid modulation and gating mechanisms of the TRPC family of ion channels.
Angiotensin-converting enzyme 2 and angiotensin 1–7: novel therapeutic targets
The ACE2-mediated catabolism of angiotensin II is likely to have a major role in cardiovascular protection, whereas the relevant functions and signalling mechanisms of actions induced by ang Elliotensin 1–7 have not been conclusively determined.
POLAR-guided signalling complex assembly and localization drive asymmetric cell division
POLAR, identified in a survey of the protein interactome of BRASSINOSTEROID INSENSITIVE 2 in Arabidopsis thaliana, has a key role in coordinating cell polarity and enabling asymmetric cell division.
Activation of AMP-activated protein kinase α2 by nicotine instigates formation of abdominal aortic aneurysms in mice in vivo
It is concluded that smoking (through nicotine) instigates AAA through AMPK-α2–mediated AP-2α–dependent MMP2 expression in cultured vascular smooth muscle cells (VSMCs) and consequent matrix metallopeptidase 2 (MMP2) gene expression.
Characterization of loss-of-inactive X in Klinefelter syndrome and female-derived cancer cells
It is found that cancer cells (PSK-1) derived from a patient with Klinefelter syndrome (47XXY) showing loss of an inactive X chromosome subsequently gained active X chromosomes.
Cryo-EM structure of oxysterol-bound human Smoothened coupled to a heterotrimeric Gi
24,25-epoxycholesterol, which is identified as an endogenous ligand of PTCH1, can stimulate Hedgehog signalling in cells and can trigger G-protein signalling via human SMO in vitro, providing molecular insights into Hedgehog signal transduction and the activation of a class-F GPCR.