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Control of landmark events in meiosis by the CDK Cdc28 and the meiosis-specific kinase Ime2.
It is speculated that several unique features of the meiotic cell division reflect a division of labor and regulatory coordination between Ime2 and Cdc28, which have critical roles in meiotic S phase and M phase. Expand
High-throughput screening using patient-derived tumor xenografts to predict clinical trial drug response
The results suggest that PCTs may represent a more accurate approach than cell line models for assessing the clinical potential of some therapeutic modalities and could potentially improve preclinical evaluation of treatmentmodalities and enhance the ability to predict clinical trial responses. Expand
Genome-wide analysis of PTB-RNA interactions reveals a strategy used by the general splicing repressor to modulate exon inclusion or skipping.
A mechanism for PTB to modulate splice site competition to produce opposite functional consequences is suggested, which may be generally applicable to RNA-binding splicing factors to positively or negatively regulate alternative splicing in mammalian cells. Expand
Phosphorylation of the Transcription Elongation Factor Spt5 by Yeast Bur1 Kinase Stimulates Recruitment of the PAF Complex
It is found that Bur1 phosphorylates the Spt5 C-terminal repeat domain (CTD) both in vivo and in isolated elongation complexes in vitro. Expand
The methodological quality assessment tools for preclinical and clinical studies, systematic review and meta‐analysis, and clinical practice guideline: a systematic review
To systematically review the methodological assessment tools for pre‐clinical and clinical studies, systematic review and meta‐analysis, and clinical practice guideline.
TFIIH-Associated Cdk7 Kinase Functions in Phosphorylation of C-Terminal Domain Ser7 Residues, Promoter-Proximal Pausing, and Termination by RNA Polymerase II
It is shown that both Cdk7 and Cdk9/PTEFb contribute to phosphorylation of Pol II CTD Ser5 residues on transcribed genes, suggesting a new role for TFIIH at 3′ ends. Expand
RAS mutations in cutaneous squamous-cell carcinomas in patients treated with BRAF inhibitors.
BACKGROUND Cutaneous squamous-cell carcinomas and keratoacanthomas are common findings in patients treated with BRAF inhibitors. METHODS We performed a molecular analysis to identify oncogenicExpand
Cdc28-Clb5 (CDK-S) and Cdc7-Dbf4 (DDK) collaborate to initiate meiotic recombination in yeast.
This work shows that the phosphorylation of Mer2 Ser30 by CDK-S primes Mer2 for subsequentosphorylation by DDK on Ser29, creating a negatively charged "patch" necessary for DSB formation, which is essential for meiotic recombination. Expand
An Unbiased Cell Morphology–Based Screen for New, Biologically Active Small Molecules
An unbiased cell morphology–based screen to identify small-molecule modulators of cellular processes using the Cytometrix (TM) automated imaging and analysis system revealed a previously unknown function for CBR1 in serum-withdrawal-induced apoptosis, and studies indicateCBR1 inhibitors may enhance the effectiveness of anticancer anthracyclines. Expand
A glutamine switch mechanism for nucleotide selectivity by phosphodiesterases.
The structure of the PDE1B structure shows that in dual-specific PDEs a key histidine residue may enable the invariant glutamine to toggle between cAMP and cGMP, and the structural understanding of nucleotide binding enables the design of new PDE inhibitors that may treat diseases in which cyclic nucleotides play a critical role. Expand