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An Arabidopsis Cell Wall Proteoglycan Consists of Pectin and Arabinoxylan Covalently Linked to an Arabinogalactan Protein[W]
TLDR
A cell wall proteoglycan with pectin and arabinoxylan covalently attached to an arabinogalactan protein is described, identifying a cross-linked matrix polysaccharide wall protein architecture with implications for wall structure, function, and synthesis.
Structure and Function of the Phosphothreonine-Specific FHA Domain
TLDR
The forkhead-associated (FHA) domain binds specifically to phosphothreonine residues and possesses unique structural and functional features and the structural bases for the novel binding specificities and multiple binding modes of FHA domains are highlighted.
The ARID domain of the H3K4 demethylase RBP2 binds to a DNA CCGCCC motif
TLDR
Immunofluorescence and luciferase assays indicated that ARID is required for RBP2 demethylase activity in cells and that DNA recognition is essential to regulate transcription.
Plant O-Hydroxyproline Arabinogalactans Are Composed of Repeating Trigalactosyl Subunits with Short Bifurcated Side Chains*
TLDR
The conformational ensemble obtained by using nuclear Overhauser effect data in structure calculations revealed a galactan main chain with a reverse turn involving the β-1→6 link between the trigalactosyl blocks, yielding a moderately compact structure stabilized by H-bonds.
Structure of the Brd4 ET domain bound to a C-terminal motif from γ-retroviral integrases reveals a conserved mechanism of interaction
TLDR
Key structural features of the ET domain of Brd4 that allow for interactions with both cellular and viral proteins are identified and suggest how BET proteins might interact with cognate binding partners involved in a diverse array of cellular phenomena including transcriptional activation, cancer, viral latency, and viral integration.
Isolation and Identification of a Paenibacillus polymyxa Strain That Coproduces a Novel Lantibiotic and Polymyxin
TLDR
A new bacterial strain, displaying potent antimicrobial properties against gram-negative and gram-positive pathogenic bacteria, was isolated from food and unequivocally characterized as a novel lantibiotic, with a high degree of posttranslational modifications.
Diphosphothreonine-specific interaction between an SQ/TQ cluster and an FHA domain in the Rad53-Dun1 kinase cascade.
TLDR
The results uncover a phospho-counting mechanism that regulates the specificity of SCD, and provide mechanistic insight into a role of multisite phosphorylation in DNA-damage signaling.
Structure of the FHA1 domain of yeast Rad53 and identification of binding sites for both FHA1 and its target protein Rad9.
TLDR
The results suggest that Thr192 of Rad9 is the likely phosphorylation site recognized by the FHA1 domain of Rad53, and the tight-binding peptide was then used to identify residues of F HA1 involved in the interaction with the pThr peptide.
Isolation of a Paenibacillus sp. Strain and Structural Elucidation of Its Broad-Spectrum Lipopeptide Antibiotic
TLDR
The new compound, designated paenibacterin, showed antagonistic activities against most Gram-positive and Gram-negative bacteria tested, including Listeria monocytogenes, methicillin-resistant Staphylococcus aureus, Escherichia coli O157:H7, and Salmonella enterica serovar Typhimurium.
Tumor suppressor INK4: comparisons of conformational properties between p16(INK4A) and p18(INK4C).
TLDR
Comparisons and analyses suggested that differences in H/(2)H exchange rates reflect differences in the kinetic stability of the INK4 proteins, which in turn is related to Differences in the aggregation tendency.
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