Contribution of Are1p and Are2p to steryl ester synthesis in the yeast Saccharomyces cerevisiae.
- D. Zweytick, E. Leitner, S. Kohlwein, C. Yu, J. Rothblatt, G. Daum
- BiologyEuropean Journal of Biochemistry
- 1 February 2000
In a growth competition experiment are1are2 cells grow more slowly than wild-type after several rounds of cultivation, suggesting that Are1p and Are2p or steryl esters, the product formed by these two enzymes, are more important in the natural environment than under laboratory conditions.
Activation of topoisomerase II-mediated excision of chromosomal DNA loops during oxidative stress.
The results demonstrate a potential role of TOP2 in oxidative damage of DNA and apoptotic cell death and show the formation of reversible HMW DNA fragments is reversible and mediated by DNA topoisomerase II (TOP2).
Chitin utilization by marine bacteria. Degradation and catabolism of chitin oligosaccharides by Vibrio furnissii.
- B. Bassler, C. Yu, Y. Lee, S. Roseman
- BiologyJournal of Biological Chemistry
- 25 December 1991
DNA minor groove-binding ligands: a different class of mammalian DNA topoisomerase I inhibitors.
- A. Y. Chen, C. Yu, B. Gatto, L. Liu
- Biology, ChemistryProceedings of the National Academy of Sciences…
- 1 September 1993
The results suggest that MGBLs, like camptothecin, abort Topo I reactions by trapping reversible cleavable complexes, and DNA topoisomerase (Topo) I may be a pharmacological target of M GBLs.
Camptothecin overcomes MDR1-mediated resistance in human KB carcinoma cells.
- A. Y. Chen, C. Yu, M. Potměšil, M. Wall, M. Wani, L. Liu
- Biology, ChemistryCancer Research
- 15 November 1991
The results suggest that the charge on camptothecin can affect the drug's sensitivity to MDR1.
Synthesis and evaluation of terbenzimidazoles as topoisomerase I inhibitors.
- Q. Sun, B. Gatto, C. Yu, A. Liu, L. Liu, E. LaVoie
- Biology, ChemistryJournal of Medicinal Chemistry
- 1 September 1995
Several terbenzimidazoles exhibited similar cytotoxicity against variants of human tumor cells that either overexpress MDR1 or are camptothecin-resistant.
Conformational study of a custom antibacterial peptide cecropin B1: implications of the lytic activity.
- S. Srisailam, A. I. Arunkumar, W. Wang, C. Yu, H. M. Chen
- ChemistryBiochimica et Biophysica Acta
- 15 June 2000
Comparison of the hemolytic activity and solution structures of two snake venom cardiotoxin analogues which only differ in their N-terminal amino acid.
- J. Jang, T. Krishnaswamy, S. Kumar, G. Jayaraman, P. Yang, C. Yu
- Chemistry, BiologyBiochemistry
- 2 December 1997
Critical analysis of the three-dimensional structures of CTX IV and CTX II reveals the presence of a "cationic" cluster comprising of positively charged residues on the concave side of the CTXIV molecule.
Snake venom cardiotoxins-structure, dynamics, function and folding.
- T. Kumar, G. Jayaraman, C. Yu
- Biology, ChemistryJournal of Biomolecular Structure and Dynamics
- 1 December 1997
This comprehensive review is to summarize and critically evaluate the progress in research on the structure, dynamics, function and folding aspects of snake venom cardiotoxins.
...
...