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Transport and Pharmacological Properties of Nine Different Human Na,K-ATPase Isozymes*
TLDR
Several new functional characteristics of human Na,K-ATPase isozymes are revealed which help to better understand their role in ion homeostasis in different tissues and in digitalis action and toxicity. Expand
Contribution of Are1p and Are2p to steryl ester synthesis in the yeast Saccharomyces cerevisiae.
TLDR
In a growth competition experiment are1are2 cells grow more slowly than wild-type after several rounds of cultivation, suggesting that Are1p and Are2p or steryl esters, the product formed by these two enzymes, are more important in the natural environment than under laboratory conditions. Expand
Molecular Cloning and Characterization of Two Isoforms of Saccharomyces cerevisiae Acyl-CoA:Sterol Acyltransferase*
TLDR
Human ACAT expressed in sat1 sat2 mutant cells can catalyze esterification of cholesterol and, to a lesser extent, ergosterol in vitro, but restores ergosteryl oleate formation in vivo to only ∼8% of that catalyzed by yeast ASAT in wild-type cells. Expand
Chitin utilization by marine bacteria. Degradation and catabolism of chitin oligosaccharides by Vibrio furnissii.
TLDR
The relative activities of the induced enzymes suggest that the rate-limiting steps in oligosaccharide catabolism are the glycosidase activities in the periplasm, particularly when the cells are confronted with low concentrations of the oligomers. Expand
DNA minor groove-binding ligands: a different class of mammalian DNA topoisomerase I inhibitors.
TLDR
The results suggest that MGBLs, like camptothecin, abort Topo I reactions by trapping reversible cleavable complexes, and DNA topoisomerase (Topo) I may be a pharmacological target of M GBLs. Expand
Role of Niemann-Pick Type C1 Protein in Intracellular Trafficking of Low Density Lipoprotein-derived Cholesterol*
TLDR
It is found that the initial movement of low density lipoprotein (LDL)-derived cholesterol to the plasma membrane (PM) did not require NPC1, but after reaching the PM and subsequent internalization, cholesterol trafficking back to the PM did involve NPC1. Expand
Activation of topoisomerase II-mediated excision of chromosomal DNA loops during oxidative stress.
TLDR
The results demonstrate a potential role of TOP2 in oxidative damage of DNA and apoptotic cell death and show the formation of reversible HMW DNA fragments is reversible and mediated by DNA topoisomerase II (TOP2). Expand
Camptothecin overcomes MDR1-mediated resistance in human KB carcinoma cells.
TLDR
The results suggest that the charge on camptothecin can affect the drug's sensitivity to MDR1. Expand
Receptor accessory folding helper enzymes: the functional role of peptidyl prolyl cis/trans isomerases
TLDR
PPIases play a critical role in the functional arrangement of components within receptor heterocomplexes. Expand
Structural Events during the Refolding of an All β-Sheet Protein*
TLDR
Results of the quenched-flow hydrogen exchange experiments reveal that the hydrogen bonds linking the N- and C-terminal ends are the first to form during the refolding of hFGF-1. Expand
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