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Molecular Diagnosis of Thiopurine S-Methyltransferase Deficiency: Genetic Basis for Azathioprine and Mercaptopurine Intolerance
Thiopurine S-methyltransferase (TPM) is a cytosolic enzyme that preferentially catalyzes the S-methylation (that is, inactivation) of such therapeutic agents as mercaptopurine, azathioprine, and… Expand
Thiopurine S-methyltransferase deficiency: two nucleotide transitions define the most prevalent mutant allele associated with loss of catalytic activity in Caucasians.
- H. L. Tai, E. Krynetski, +4 authors W. Evans
- Biology, Medicine
- American journal of human genetics
- 1 April 1996
The autosomal recessive trait of thiopurine S-methytransferase (TPMT) deficiency is associated with severe hematopoietic toxicity when patients are treated with standard doses of mercaptopurine,… Expand
Genetic polymorphism of thiopurine S-methyltransferase: clinical importance and molecular mechanisms.
Thiopurine S-methyltransferase (TPMT) catalyses the S-methylation of thiopurines such as mercaptopurine and thioguanine. TPMT activity exhibits genetic polymorphism, with about 1 in 300 inheriting… Expand
Novel polymorphisms in the myosin light chain kinase gene confer risk for acute lung injury.
- Li Gao, A. Grant, +16 authors J. Garcia
- Biology, Medicine
- American journal of respiratory cell and…
- 1 April 2006
The genetic basis of acute lung injury (ALI) is poorly understood. The myosin light chain kinase (MYLK) gene encodes the nonmuscle myosin light chain kinase isoform, a multifunctional protein… Expand
Macrophage migration inhibitory factor in acute lung injury: expression, biomarker, and associations.
The macrophage migration inhibitory factor (MIF), a pro-inflammatory cytokine central to the response to endotoxemia, is a putative biomarker in acute lung injury (ALI). To explore MIF as a molecular… Expand
In vivo evidence for a novel pathway of vitamin D3 metabolism initiated by P450scc and modified by CYP27B1
- A. Slominski, Tae-Kang Kim, +11 authors R. Tuckey
- Medicine, Biology
- FASEB journal : official publication of the…
- 8 June 2012
We define previously unrecognized in vivo pathways of vitamin D3 (D3) metabolism generating novel D3‐hydroxyderivatives different from 25‐hydroxyvitamin D3 [25(OH)D3] and 1,25(OH)2D3. Their novel… Expand
The Effect of CYP3A5 and MDR1 Polymorphic Expression on Cyclosporine Oral Disposition in Renal Transplant Patients
Variability in CYP3A (CYP3A4/5) and P‐glycoprotein (human MDR1 gene product) activity underlies interindividual differences in oral cyclosporine (CsA) bioavailability. Racial differences in… Expand
Pharmacokinetics of immunosuppressants: a perspective on ethnic differences.
- N. L. Dirks, B. Huth, C. Yates, B. Meibohm
- International journal of clinical pharmacology…
- 1 December 2004
Despite recent advancements in solid organ transplantation, African-American renal allograft recipients continue to exhibit poorer prognosis in long-term clinical outcome and graft survival compared… Expand
Structural Determinants of P-Glycoprotein-Mediated Transport of Glucocorticoids
AbstractPurpose. The aim of this study was to determine requisite structural features for P-glycoprotein-mediated transport of a series of structurally related glucocorticoids (GCs). Methods.… Expand
Polycystin-1 interacts with TAZ to stimulate osteoblastogenesis and inhibit adipogenesis
- Z. Xiao, Jerome Baudry, +8 authors L. Quarles
- Chemistry, Medicine
- The Journal of clinical investigation
- 2 January 2018
The molecular mechanisms that transduce the osteoblast response to physical forces in the bone microenvironment are poorly understood. Here, we used genetic and pharmacological experiments to… Expand