• Publications
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Analysis of plasma and urinary tea polyphenols in human subjects.
  • M. Lee, Z. Wang, +5 authors C. Yang
  • Chemistry, Medicine
  • Cancer epidemiology, biomarkers & prevention : a…
  • 1 June 1995
Methods for the analysis of tea polyphenols in human plasma and urine samples using HPLC with the coulochem electrode array detection system to develop biomarkers for tea consumption established good quantitative relationships for a large concentration range of teapolyphenols. Expand
Hydroxylation of chlorzoxazone as a specific probe for human liver cytochrome P-450IIE1.
Results provide strong evidence that P-450IIE1 is the primary catalyst of chlorzoxazone 6-hydroxylation in human liver and may have potential use as a noninvasive probe in estimating the in vivo expression of the protein. Expand
Inhibition of carcinogenesis by dietary polyphenolic compounds.
This chapter reviews the inhibition of tumorigenesis by phenolic acids and derivatives, tea and catechins, isoflavones and soy preparations, quercetin and other flavonoids, resveratrol, and lignans as well as the mechanisms involved based on studies in vivo and in vitro. Expand
Blood and urine levels of tea catechins after ingestion of different amounts of green tea by human volunteers.
The inhibitory activity of tea against tumorigenesis has been demonstrated in many animal models and has been suggested by some epidemiological studies. Such activity has generally been attributed toExpand
Cytochrome P450 enzymes involved in acetaminophen activation by rat and human liver microsomes and their kinetics.
Using this approach, involvement of enzymes in the activation of APAP and their kinetics were studied and substantial activity was observed in rat liver microsomes and human P450s expressed in Hep G2 cells. Expand
Inhibition of carcinogenesis by tea.
Tea has received a great deal of attention because tea polyphenols are strong antioxidants, and tea preparations have inhibitory activity against tumorigenesis, but epidemiological studies have not yielded clear conclusions concerning the protective effects of tea consumption against cancer formation in humans. Expand
Tea and cancer.
  • C. Yang, Z. Wang
  • Medicine
  • Journal of the National Cancer Institute
  • 7 July 1993
A critical review of the relationship between tea consumption and human cancer risk is provided, covering basic chemistry and biochemical activity of tea, epidemiologic investigations, and laboratory studies, as well as possible directions for future research. Expand
Inhibition of cytochrome P-450 2E1 by diallyl sulfide and its metabolites.
The results suggest that diallyl sulfide inhibits the metabolism of P- 450 2E1 substrates by competitive inhibition mechanisms and by inactivating P-450 2 E1 via a suicide-inhibitory action of DASO2. Expand
Phase I pharmacokinetic study of tea polyphenols following single-dose administration of epigallocatechin gallate and polyphenon E.
  • H. Chow, Y. Cai, +6 authors Y. Hara
  • Chemistry, Medicine
  • Cancer epidemiology, biomarkers & prevention : a…
  • 2001
The systemic availability of EGCG increased at higher doses, possibly due to saturable presystemic elimination of orally administered green tea polyphenols, and EGC and EC were present in the body after the Polyphenon E administration; however, they were present predominantly in conjugated forms. Expand
Plasma and Tissue Levels of Tea Catechins in Rats and Mice During Chronic Consumption of Green Tea Polyphenols
It is suggested that consumption of tea by rodents could induce adaptive responses affecting blood and tissue levels of tea catechins with time and that investigation of a similar phenomenon in humans is warranted. Expand